KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference
Identifieur interne : 002516 ( Main/Exploration ); précédent : 002515; suivant : 002517KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference
Auteurs : Gunter Schumann [Royaume-Uni] ; Chunyu Liu ; Paul O Eilly [Royaume-Uni] ; He Gao [Royaume-Uni] ; Parkyong Song ; Bing Xu [Royaume-Uni] ; Barbara Ruggeri [Royaume-Uni] ; Najaf Amin [Pays-Bas] ; Tianye Jia [Royaume-Uni] ; Sarah Preis ; Marcelo Segura Lepe [Royaume-Uni, Allemagne] ; Shizuo Akira [Japon] ; Caterina Barbieri [Italie] ; Sebastian Baumeister [Allemagne] ; Stephane Cauchi [France] ; Toni-Kim Clarke [Royaume-Uni] ; Stefan Enroth [Suède] ; Krista Fischer [Estonie] ; Jenni H Llfors [Finlande] ; Sarah E. Harris [Royaume-Uni] ; Saskia Hieber [Allemagne] ; Edith Hofer [Autriche] ; Jouke-Jan Hottenga [Pays-Bas] ; Sa Johansson [Suède] ; Peter K. Joshi [Royaume-Uni] ; Niina Kaartinen [Finlande] ; Jaana Laitinen [Finlande] ; Rozenn Lemaitre ; Anu Loukola [Finlande] ; Jian N Luan [Royaume-Uni] ; Leo-Pekka Lyytik Inen [Finlande] ; Massimo Mangino [Royaume-Uni] ; Ani Manichaikul ; Hamdi Mbarek [Pays-Bas] ; Yuri Milaneschi [Pays-Bas] ; Alireza Moayyeri [Royaume-Uni] ; Kenneth Mukamal ; Christopher Nelson [Royaume-Uni] ; Jennifer Nettleton ; Eemil Partinen [Estonie] ; Rajesh Rawal [Allemagne] ; Antonietta Robino [Italie] ; Lynda Rose ; Cinzia Sala [Italie] ; Takashi Satoh [Japon] ; Reinhold Schmidt [Autriche] ; Katharina Schraut [Royaume-Uni] ; Robert Scott [Royaume-Uni] ; Albert Vernon Smith [Islande] ; John M. Starr [Royaume-Uni] ; Alexander Teumer [Allemagne] ; Stella Trompet [Pays-Bas] ; André G. Uitterlinden [Pays-Bas] ; Cristina Venturini [Royaume-Uni] ; Anne-Claire Vergnaud [Royaume-Uni] ; Niek Verweij [Pays-Bas] ; Veronique Vitart [Royaume-Uni] ; Dragana Vuckovic [Italie] ; Juho Wedenoja [Finlande] ; Loic Yengo [France] ; Bing Yu ; Weihua Zhang [Royaume-Uni] ; Jing Hua Zhao [Royaume-Uni] ; Dorret I. Boomsma [Pays-Bas] ; John Chambers [Royaume-Uni] ; Daniel I. Chasman ; Toniolo Daniela [Italie] ; Eco De Geus [Pays-Bas] ; Ian Deary [Royaume-Uni] ; Johan G. Eriksson [Finlande] ; T Nu Esko [Estonie] ; Volker Eulenburg [Allemagne] ; Oscar H. Franco [Pays-Bas] ; Philippe Froguel [France, Royaume-Uni] ; Christian Gieger [Allemagne] ; Hans J. Grabe [Allemagne] ; Vilmundur Gudnason [Islande] ; Ulf Gyllensten [Suède] ; Tamara B. Harris ; Anna-Liisa Hartikainen [Finlande] ; Andrew C. Heath ; Lynne Hocking [Royaume-Uni] ; Albert Hofman [Pays-Bas] ; Cornelia Huth [Allemagne] ; Marjo-Riitta Jarvelin [Royaume-Uni, Finlande] ; J. Wouter Jukema [Pays-Bas] ; Jaakko Kaprio [Finlande] ; Jaspal S. Kooner [Royaume-Uni] ; Zoltan Kutalik [Suisse] ; Jari Lahti [Finlande] ; Claudia Langenberg [Royaume-Uni] ; Terho Lehtim Ki [Finlande] ; Yongmei Liu ; Pamela A. F. Madden ; Nicholas Martin [Australie] ; Alanna Morrison ; Brenda Penninx [Pays-Bas] ; Nicola Pirastu [Royaume-Uni, Italie] ; Bruce Psaty ; Olli Raitakari [Finlande] ; Paul Ridker ; Richard Rose ; Jerome I. Rotter ; Nilesh J. Samani [Royaume-Uni] ; Helena Schmidt [Autriche] ; Tim D. Spector [Royaume-Uni] ; David Stott [Royaume-Uni] ; David Strachan [Royaume-Uni] ; Ioanna Tzoulaki [Royaume-Uni, Grèce] ; Pim Van Der Harst [Pays-Bas] ; Cornelia M. Van Duijn [Pays-Bas] ; Pedro Marques-Vidal [Suisse] ; Peter Vollenweider [Suisse] ; Nicholas J. Wareham [Royaume-Uni] ; John B. Whitfield [Australie] ; James Wilson [Royaume-Uni] ; Bruce Wolffenbuttel [Pays-Bas] ; Georgy Bakalkin [Suède] ; Evangelos Evangelou [Royaume-Uni, Grèce] ; Yun Liu [République populaire de Chine] ; Kenneth M. Rice ; Sylvane Desrivières [Royaume-Uni] ; Steven A. Kliewer ; David J. Mangelsdorf ; Christian P. Müller [Allemagne] ; Daniel Levy ; Paul Elliott [Royaume-Uni]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2016.
Abstract
Alcohol is a widely consumed drug in western societies that can lead to addiction. A small shift in consumption can have dramatic consequences on public health. We performed the largest genome-wide association metaanalysis and replication study to date (>105,000 individuals) and identified a genetic basis for alcohol consumption during nonaddictive drinking. We found that a locus in the gene encoding β-Klotho is associated with alcohol consumption. β-Klotho is an essential receptor component for the endocrine FGFs, FGF19 and FGF21. Using mouse models and pharmacologic administration of FGF21, we show that β-Klotho in the brain controls alcohol drinking. These findings reveal a mechanism regulating alcohol consumption in humans that may be pharmacologically tractable for reducing alcohol intake.
Url:
DOI: 10.1073/pnas.1611243113
PubMed: 27911795
PubMed Central: 5167198
Affiliations:
- Allemagne, Australie, Autriche, Estonie, Finlande, France, Grèce, Islande, Italie, Japon, Pays-Bas, Royaume-Uni, République populaire de Chine, Suisse, Suède
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001C11
- to stream Pmc, to step Curation: 001A69
- to stream Pmc, to step Checkpoint: 000B98
- to stream PubMed, to step Corpus: 001495
- to stream PubMed, to step Curation: 001473
- to stream PubMed, to step Checkpoint: 001473
- to stream Ncbi, to step Merge: 003F77
- to stream Ncbi, to step Curation: 003F77
- to stream Ncbi, to step Checkpoint: 003F77
- to stream Main, to step Merge: 002515
- to stream Main, to step Curation: 002516
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>KLB</italic> is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference</title><author><name sortKey="Schumann, Gunter" sort="Schumann, Gunter" uniqKey="Schumann G" first="Gunter" last="Schumann">Gunter Schumann</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council—Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Chunyu" sort="Liu, Chunyu" uniqKey="Liu C" first="Chunyu" last="Liu">Chunyu Liu</name><affiliation><nlm:aff id="aff2"><institution>The Framingham Heart Study</institution>, Framingham,<addr-line>MA</addr-line> 01702;</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">The Population Sciences Branch, Division of Intramural Research,<institution>National Heart, Lung, and Blood Institute</institution>, Bethesda,<addr-line>MD</addr-line> 20824;</nlm:aff></affiliation><affiliation><nlm:aff id="aff4"><institution>Department of Biostatistics, Boston University School of Public Health</institution>, Boston,<addr-line>MA</addr-line> 02118;</nlm:aff></affiliation></author><author><name sortKey="O Eilly, Paul" sort="O Eilly, Paul" uniqKey="O Eilly P" first="Paul" last="O Eilly">Paul O Eilly</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council—Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gao, He" sort="Gao, He" uniqKey="Gao H" first="He" last="Gao">He Gao</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Medical Research Council-Public Health England Centre for Environment and Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Song, Parkyong" sort="Song, Parkyong" uniqKey="Song P" first="Parkyong" last="Song">Parkyong Song</name><affiliation><nlm:aff id="aff7">Department of Pharmacology,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390;</nlm:aff></affiliation><affiliation><nlm:aff id="aff8"><institution>Howard Hughes Medical Institute</institution>,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390;</nlm:aff></affiliation></author><author><name sortKey="Xu, Bing" sort="Xu, Bing" uniqKey="Xu B" first="Bing" last="Xu">Bing Xu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council—Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ruggeri, Barbara" sort="Ruggeri, Barbara" uniqKey="Ruggeri B" first="Barbara" last="Ruggeri">Barbara Ruggeri</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council—Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation wicri:level="1"><nlm:aff id="aff9">Genetic Epidemiology Unit, Department of Epidemiology,<institution>Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jia, Tianye" sort="Jia, Tianye" uniqKey="Jia T" first="Tianye" last="Jia">Tianye Jia</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council—Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Preis, Sarah" sort="Preis, Sarah" uniqKey="Preis S" first="Sarah" last="Preis">Sarah Preis</name><affiliation><nlm:aff id="aff4"><institution>Department of Biostatistics, Boston University School of Public Health</institution>, Boston,<addr-line>MA</addr-line> 02118;</nlm:aff></affiliation></author><author><name sortKey="Segura Lepe, Marcelo" sort="Segura Lepe, Marcelo" uniqKey="Segura Lepe M" first="Marcelo" last="Segura Lepe">Marcelo Segura Lepe</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Section of Bioinformatics, Bayer Pharma AG</institution>, 13342 Berlin,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Akira, Shizuo" sort="Akira, Shizuo" uniqKey="Akira S" first="Shizuo" last="Akira">Shizuo Akira</name><affiliation wicri:level="1"><nlm:aff id="aff11">Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Research Institute for Microbial Diseases,<institution>Osaka University</institution>, Osaka 565-0871,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barbieri, Caterina" sort="Barbieri, Caterina" uniqKey="Barbieri C" first="Caterina" last="Barbieri">Caterina Barbieri</name><affiliation wicri:level="1"><nlm:aff id="aff12">Division of Genetics and Cell Biology,<institution>San Raffaele Research Institute</institution>, 20132 Milan,<country>Italy</country>;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Baumeister, Sebastian" sort="Baumeister, Sebastian" uniqKey="Baumeister S" first="Sebastian" last="Baumeister">Sebastian Baumeister</name><affiliation wicri:level="1"><nlm:aff id="aff13">Institute for Community Medicine,<institution>University Medicine Greifswald</institution>, Greifswald 17475,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff14">Department of Epidemiology and Preventive Medicine,<institution>University of Regensburg</institution>, 93053 Regensburg,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cauchi, Stephane" sort="Cauchi, Stephane" uniqKey="Cauchi S" first="Stephane" last="Cauchi">Stephane Cauchi</name><affiliation wicri:level="1"><nlm:aff id="aff15">CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes,<institution>Lille 2 University</institution>, 59000 Lille,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Clarke, Toni Kim" sort="Clarke, Toni Kim" uniqKey="Clarke T" first="Toni-Kim" last="Clarke">Toni-Kim Clarke</name><affiliation wicri:level="1"><nlm:aff id="aff16">Divison of Psychiatry,<institution>University of Edinburgh</institution>, Edinburgh EH10 5HF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Enroth, Stefan" sort="Enroth, Stefan" uniqKey="Enroth S" first="Stefan" last="Enroth">Stefan Enroth</name><affiliation wicri:level="1"><nlm:aff id="aff17">Science for Life Laboratory, Department of Immunology, Genetics and Pathology,<institution>Uppsala University</institution>, 75108 Uppsala,<country>Sweden</country>;</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name><affiliation wicri:level="1"><nlm:aff id="aff18">Estonian Genome Center,<institution>University of Tartu</institution>, 51010 Tartu,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="H Llfors, Jenni" sort="H Llfors, Jenni" uniqKey="H Llfors J" first="Jenni" last="H Llfors">Jenni H Llfors</name><affiliation wicri:level="1"><nlm:aff id="aff19">Institute for Molecular Medicine,<institution>University of Helsinki</institution>, 00290 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Sarah E" sort="Harris, Sarah E" uniqKey="Harris S" first="Sarah E." last="Harris">Sarah E. Harris</name><affiliation wicri:level="1"><nlm:aff id="aff20">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff21">Centre for Genomic and Experimental Medicine,<institution>University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hieber, Saskia" sort="Hieber, Saskia" uniqKey="Hieber S" first="Saskia" last="Hieber">Saskia Hieber</name><affiliation wicri:level="1"><nlm:aff id="aff22">Department of Psychiatry and Psychotherapy,<institution>Friedrich Alexander University Erlangen-Nuremberg</institution>, 91054 Erlangen,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hofer, Edith" sort="Hofer, Edith" uniqKey="Hofer E" first="Edith" last="Hofer">Edith Hofer</name><affiliation wicri:level="1"><nlm:aff id="aff23">Clinical Division of Neurogeriatrics, Department of Neurology,<institution>Medical University Graz</institution>, 8036 Graz,<country>Austria</country>;</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff24">Institute of Medical Informatics, Statistics and Documentation,<institution>Medical University Graz</institution>, 8036 Graz,<country>Austria</country>;</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation wicri:level="1"><nlm:aff id="aff25">Department of Biological Psychology,<institution>Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research</institution>, 1081 BT Amsterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation wicri:level="1"><nlm:aff id="aff17">Science for Life Laboratory, Department of Immunology, Genetics and Pathology,<institution>Uppsala University</institution>, 75108 Uppsala,<country>Sweden</country>;</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Joshi, Peter K" sort="Joshi, Peter K" uniqKey="Joshi P" first="Peter K." last="Joshi">Peter K. Joshi</name><affiliation wicri:level="1"><nlm:aff id="aff26">Usher Institute for Population Health Sciences and Informatics,<institution>University of Edinburgh</institution>, Edinburgh EH8 9AG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kaartinen, Niina" sort="Kaartinen, Niina" uniqKey="Kaartinen N" first="Niina" last="Kaartinen">Niina Kaartinen</name><affiliation wicri:level="1"><nlm:aff id="aff27"><institution>National Institute for Health and Welfare</institution>, 00271 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Laitinen, Jaana" sort="Laitinen, Jaana" uniqKey="Laitinen J" first="Jaana" last="Laitinen">Jaana Laitinen</name><affiliation wicri:level="1"><nlm:aff id="aff28"><institution>Quantified Employee-Unit, Finnish Institute of Occupational Health</institution>, 00250 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lemaitre, Rozenn" sort="Lemaitre, Rozenn" uniqKey="Lemaitre R" first="Rozenn" last="Lemaitre">Rozenn Lemaitre</name><affiliation><nlm:aff id="aff29">Cardiovascular Health Research Unit, Department of Medicine,<institution>University of Washington</institution>, Seattle,<addr-line>WA</addr-line> 98101;</nlm:aff></affiliation></author><author><name sortKey="Loukola, Anu" sort="Loukola, Anu" uniqKey="Loukola A" first="Anu" last="Loukola">Anu Loukola</name><affiliation wicri:level="1"><nlm:aff id="aff19">Institute for Molecular Medicine,<institution>University of Helsinki</institution>, 00290 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff30">Department of Public Health,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Luan, Jian N" sort="Luan, Jian N" uniqKey="Luan J" first="Jian N" last="Luan">Jian N Luan</name><affiliation wicri:level="1"><nlm:aff id="aff31">Medical Research Council Epidemiology Unit, Institute of Metabolic Science,<institution>University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0QQ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name><affiliation wicri:level="1"><nlm:aff id="aff32">Department of Clinical Chemistry,<institution>Fimlab Laboratories and University of Tampere School of Medicine</institution>, Tampere 33520,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation wicri:level="1"><nlm:aff id="aff33">Department of Twin Research and Genetic Epidemiology,<institution>King’s College</institution>, London SE1 7EH,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff34"><institution>National Institute for Health Research Biomedical Research Centre at Guy’s and St. Thomas’ Foundation Trust</institution>, London SE1 9RT, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>, London SE1 9RT</wicri:regionArea><wicri:noRegion>London SE1 9RT</wicri:noRegion></affiliation></author><author><name sortKey="Manichaikul, Ani" sort="Manichaikul, Ani" uniqKey="Manichaikul A" first="Ani" last="Manichaikul">Ani Manichaikul</name><affiliation><nlm:aff id="aff35">Center for Public Health Genomics, Department of Public Health Sciences,<institution>University of Virginia</institution>, Charlottesville,<addr-line>VA</addr-line> 22903;</nlm:aff></affiliation><affiliation><nlm:aff id="aff36">Biostatistics Section, Department of Public Health Sciences,<institution>University of Virginia</institution>, Charlottesville,<addr-line>VA</addr-line> 22903;</nlm:aff></affiliation></author><author><name sortKey="Mbarek, Hamdi" sort="Mbarek, Hamdi" uniqKey="Mbarek H" first="Hamdi" last="Mbarek">Hamdi Mbarek</name><affiliation wicri:level="1"><nlm:aff id="aff25">Department of Biological Psychology,<institution>Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research</institution>, 1081 BT Amsterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Milaneschi, Yuri" sort="Milaneschi, Yuri" uniqKey="Milaneschi Y" first="Yuri" last="Milaneschi">Yuri Milaneschi</name><affiliation wicri:level="1"><nlm:aff id="aff37">Department of Psychiatry, Institute for Health and Care Research (EMGO) Institute for Health and Care Research and Neuroscience Campus Amsterdam,<institution>Vrije Universiteit Amsterdam University Medical Center/Geestelijke Gezondheids Zorg (GGZ) inGeest</institution>, 1081 HL Amsterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Moayyeri, Alireza" sort="Moayyeri, Alireza" uniqKey="Moayyeri A" first="Alireza" last="Moayyeri">Alireza Moayyeri</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff38">Institute of Health Informatics,<institution>University College London</institution>, London NW1 2DA,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff39"><institution>Farr Institute of Health Informatics Research</institution>, University College London Institute of Health Informatics, London NW1 2DA,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mukamal, Kenneth" sort="Mukamal, Kenneth" uniqKey="Mukamal K" first="Kenneth" last="Mukamal">Kenneth Mukamal</name><affiliation><nlm:aff id="aff40">Department of Medicine,<institution>Beth Israel Deaconess Medical Center and Harvard Medical School</institution>, Boston,<addr-line>MA</addr-line> 02215;</nlm:aff></affiliation></author><author><name sortKey="Nelson, Christopher" sort="Nelson, Christopher" uniqKey="Nelson C" first="Christopher" last="Nelson">Christopher Nelson</name><affiliation wicri:level="1"><nlm:aff id="aff41">Department of Cardiovascular Sciences, University of Leicester,<institution>Glenfield Hospital</institution>, Leicester LE3 9QP,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff42">National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit,<institution>Glenfield Hospital</institution>, Leicester LE3 9QP,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nettleton, Jennifer" sort="Nettleton, Jennifer" uniqKey="Nettleton J" first="Jennifer" last="Nettleton">Jennifer Nettleton</name><affiliation><nlm:aff id="aff43">Division of Epidemiology, Human Genetics, and Environmental Sciences,<institution>University of Texas Health Sciences Center</institution>, Houston,<addr-line>TX</addr-line> 77225;</nlm:aff></affiliation></author><author><name sortKey="Partinen, Eemil" sort="Partinen, Eemil" uniqKey="Partinen E" first="Eemil" last="Partinen">Eemil Partinen</name><affiliation wicri:level="1"><nlm:aff id="aff44">Faculty of Medicine,<institution>University of Tartu</institution>, 50411 Tartu,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rawal, Rajesh" sort="Rawal, Rajesh" uniqKey="Rawal R" first="Rajesh" last="Rawal">Rajesh Rawal</name><affiliation wicri:level="1"><nlm:aff id="aff45">Department of Molecular Epidemiology, Institute of Epidemiology II,<institution>Helmholtz Zentrum München</institution>, 85764 Neuherberg,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Robino, Antonietta" sort="Robino, Antonietta" uniqKey="Robino A" first="Antonietta" last="Robino">Antonietta Robino</name><affiliation wicri:level="1"><nlm:aff id="aff46"><institution>Institute for Maternal and Child Health—Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Burlo Garofolo</institution>, 34137 Trieste,<country>Italy</country>;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rose, Lynda" sort="Rose, Lynda" uniqKey="Rose L" first="Lynda" last="Rose">Lynda Rose</name><affiliation><nlm:aff id="aff47">Division of Preventive Medicine,<institution>Brigham and Women’s Hospital</institution>, Boston,<addr-line>MA</addr-line> 02215;</nlm:aff></affiliation></author><author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name><affiliation wicri:level="1"><nlm:aff id="aff12">Division of Genetics and Cell Biology,<institution>San Raffaele Research Institute</institution>, 20132 Milan,<country>Italy</country>;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Satoh, Takashi" sort="Satoh, Takashi" uniqKey="Satoh T" first="Takashi" last="Satoh">Takashi Satoh</name><affiliation wicri:level="1"><nlm:aff id="aff11">Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Research Institute for Microbial Diseases,<institution>Osaka University</institution>, Osaka 565-0871,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation wicri:level="1"><nlm:aff id="aff23">Clinical Division of Neurogeriatrics, Department of Neurology,<institution>Medical University Graz</institution>, 8036 Graz,<country>Austria</country>;</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schraut, Katharina" sort="Schraut, Katharina" uniqKey="Schraut K" first="Katharina" last="Schraut">Katharina Schraut</name><affiliation wicri:level="1"><nlm:aff id="aff26">Usher Institute for Population Health Sciences and Informatics,<institution>University of Edinburgh</institution>, Edinburgh EH8 9AG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Scott, Robert" sort="Scott, Robert" uniqKey="Scott R" first="Robert" last="Scott">Robert Scott</name><affiliation wicri:level="1"><nlm:aff id="aff48">Medical Research Council Epidemiology Unit,<institution>University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0QQ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name><affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Research Institute, Icelandic Heart Association</institution>, 201 Kopavogur,<country>Iceland</country>;</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><affiliation wicri:level="1"><nlm:aff id="aff20">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff50">Alzheimer Scotland Research Centre,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation wicri:level="1"><nlm:aff id="aff13">Institute for Community Medicine,<institution>University Medicine Greifswald</institution>, Greifswald 17475,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff51">Interfaculty Institute for Genetics and Functional Genomics,<institution>University Medicine Greifswald</institution>, 17475 Greifswald,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name><affiliation wicri:level="1"><nlm:aff id="aff52">Department of Cardiology,<institution>Leiden University Medical Center</institution>, 2300 RC Leiden,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff53">Department of Gerontology and Geriatrics,<institution>Leiden University Medical Center</institution>, 2300 RC Leiden,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G." last="Uitterlinden">André G. Uitterlinden</name><affiliation wicri:level="1"><nlm:aff id="aff54">Department of internal Medicine,<institution>Erasmus Medical Center</institution>, 3015 CN Rotterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff55">Department of Epidemiology,<institution>Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Venturini, Cristina" sort="Venturini, Cristina" uniqKey="Venturini C" first="Cristina" last="Venturini">Cristina Venturini</name><affiliation wicri:level="1"><nlm:aff id="aff33">Department of Twin Research and Genetic Epidemiology,<institution>King’s College</institution>, London SE1 7EH,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vergnaud, Anne Claire" sort="Vergnaud, Anne Claire" uniqKey="Vergnaud A" first="Anne-Claire" last="Vergnaud">Anne-Claire Vergnaud</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name><affiliation wicri:level="1"><nlm:aff id="aff56">Department of Cardiology, University Medical Center Groningen,<institution>University of Groningen</institution>, 9700RB Groningen,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation wicri:level="1"><nlm:aff id="aff57">Medical Research Council Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh,<institution>Western General Hospital</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vuckovic, Dragana" sort="Vuckovic, Dragana" uniqKey="Vuckovic D" first="Dragana" last="Vuckovic">Dragana Vuckovic</name><affiliation wicri:level="1"><nlm:aff id="aff58">Department of Medical Sciences,<institution>University of Trieste</institution>, 34149 Trieste,<country>Italy</country>;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wedenoja, Juho" sort="Wedenoja, Juho" uniqKey="Wedenoja J" first="Juho" last="Wedenoja">Juho Wedenoja</name><affiliation wicri:level="1"><nlm:aff id="aff30">Department of Public Health,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yengo, Loic" sort="Yengo, Loic" uniqKey="Yengo L" first="Loic" last="Yengo">Loic Yengo</name><affiliation wicri:level="1"><nlm:aff id="aff15">CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes,<institution>Lille 2 University</institution>, 59000 Lille,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yu, Bing" sort="Yu, Bing" uniqKey="Yu B" first="Bing" last="Yu">Bing Yu</name><affiliation><nlm:aff id="aff59">Human Genetics Center,<institution>University of Texas Health Science Center at Houston</institution>, Houston,<addr-line>TX</addr-line> 77225;</nlm:aff></affiliation><affiliation><nlm:aff id="aff60">Division of Epidemiology,<institution>University of Texas Health Science Center at Houston</institution>, Houston,<addr-line>TX</addr-line> 77225;</nlm:aff></affiliation></author><author><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff61">Department of Cardiology,<institution>Ealing Hospital</institution>, Middlesex UB1 3HW,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation wicri:level="1"><nlm:aff id="aff48">Medical Research Council Epidemiology Unit,<institution>University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0QQ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation wicri:level="1"><nlm:aff id="aff25">Department of Biological Psychology,<institution>Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research</institution>, 1081 BT Amsterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chambers, John" sort="Chambers, John" uniqKey="Chambers J" first="John" last="Chambers">John Chambers</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff61">Department of Cardiology,<institution>Ealing Hospital</institution>, Middlesex UB1 3HW,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff62"><institution>Imperial College Healthcare National Health Service Trust</institution>, London W12 0HS,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name><affiliation><nlm:aff id="aff47">Division of Preventive Medicine,<institution>Brigham and Women’s Hospital</institution>, Boston,<addr-line>MA</addr-line> 02215;</nlm:aff></affiliation><affiliation><nlm:aff id="aff63"><institution>Harvard Medical School</institution>, Boston,<addr-line>MA</addr-line> 02115;</nlm:aff></affiliation></author><author><name sortKey="Daniela, Toniolo" sort="Daniela, Toniolo" uniqKey="Daniela T" first="Toniolo" last="Daniela">Toniolo Daniela</name><affiliation wicri:level="1"><nlm:aff id="aff12">Division of Genetics and Cell Biology,<institution>San Raffaele Research Institute</institution>, 20132 Milan,<country>Italy</country>;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Geus, Eco" sort="De Geus, Eco" uniqKey="De Geus E" first="Eco" last="De Geus">Eco De Geus</name><affiliation wicri:level="1"><nlm:aff id="aff25">Department of Biological Psychology,<institution>Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research</institution>, 1081 BT Amsterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deary, Ian" sort="Deary, Ian" uniqKey="Deary I" first="Ian" last="Deary">Ian Deary</name><affiliation wicri:level="1"><nlm:aff id="aff20">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff64">Psychology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G." last="Eriksson">Johan G. Eriksson</name><affiliation wicri:level="1"><nlm:aff id="aff27"><institution>National Institute for Health and Welfare</institution>, 00271 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff65">Department of General Practice and Primary Health Care,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff66">Unit of General Practice,<institution>Helsinki University Central Hospital</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff67"><institution>Folkhälsan Research Centre</institution>, Public Health Research, 00290 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff68"><institution>Vasa Central Hospital</institution>, 65130 Vasa,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation wicri:level="1"><nlm:aff id="aff18">Estonian Genome Center,<institution>University of Tartu</institution>, 51010 Tartu,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eulenburg, Volker" sort="Eulenburg, Volker" uniqKey="Eulenburg V" first="Volker" last="Eulenburg">Volker Eulenburg</name><affiliation wicri:level="1"><nlm:aff id="aff69">Institute for Biochemistry and Molecular Medicine,<institution>Friedrich Alexander University Erlangen-Nuremberg</institution>, 91054 Erlangen,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H." last="Franco">Oscar H. Franco</name><affiliation wicri:level="1"><nlm:aff id="aff55">Department of Epidemiology,<institution>Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation wicri:level="1"><nlm:aff id="aff15">CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes,<institution>Lille 2 University</institution>, 59000 Lille,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff70">Department of Genomics of Common Disease, School of Public Health,<institution>Imperial College London</institution>, London W12 0HR,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation wicri:level="1"><nlm:aff id="aff45">Department of Molecular Epidemiology, Institute of Epidemiology II,<institution>Helmholtz Zentrum München</institution>, 85764 Neuherberg,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Grabe, Hans J" sort="Grabe, Hans J" uniqKey="Grabe H" first="Hans J." last="Grabe">Hans J. Grabe</name><affiliation wicri:level="1"><nlm:aff id="aff71">Department of Psychiatry and Psychotherapy,<institution>University Medicine Greifswald</institution>, 17475 Greifswald,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Research Institute, Icelandic Heart Association</institution>, 201 Kopavogur,<country>Iceland</country>;</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff72">Faculty of Medicine,<institution>University of Iceland</institution>, 101 Reykjavik,<country>Iceland</country>;</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation wicri:level="1"><nlm:aff id="aff17">Science for Life Laboratory, Department of Immunology, Genetics and Pathology,<institution>Uppsala University</institution>, 75108 Uppsala,<country>Sweden</country>;</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="aff73">National Institute on Aging,<institution>NIH</institution>, Bethesda,<addr-line>MD</addr-line> 20892;</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation wicri:level="1"><nlm:aff id="aff74">Department of Obstetrics and Gynecology,<institution>Oulu University Hospital</institution>, 90029 Oulu,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff75">Medical Research Center,<institution>University of Oulu</institution>, 90014 Oulu,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff76">Unit of Primary Care,<institution>Oulu University Hospital</institution>, 90220 Oulu,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Heath, Andrew C" sort="Heath, Andrew C" uniqKey="Heath A" first="Andrew C." last="Heath">Andrew C. Heath</name><affiliation><nlm:aff id="aff77">Department of Psychiatry,<institution>Washington University School of Medicine in St. Louis</institution>, St. Louis,<addr-line>MO</addr-line> 63110;</nlm:aff></affiliation></author><author><name sortKey="Hocking, Lynne" sort="Hocking, Lynne" uniqKey="Hocking L" first="Lynne" last="Hocking">Lynne Hocking</name><affiliation wicri:level="1"><nlm:aff id="aff78">Institute of Medical Sciences,<institution>University of Aberdeen</institution>, Aberdeen AB25 2ZD,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><nlm:aff id="aff55">Department of Epidemiology,<institution>Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huth, Cornelia" sort="Huth, Cornelia" uniqKey="Huth C" first="Cornelia" last="Huth">Cornelia Huth</name><affiliation wicri:level="1"><nlm:aff id="aff79">Institute of Epidemiology II, Helmholtz Zentrum München,<institution>German Research Center for Environmental Health GmbH</institution>, D-85764 Neuherberg,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff76">Unit of Primary Care,<institution>Oulu University Hospital</institution>, 90220 Oulu,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff80">Center for Life Course Epidemiology, Faculty of Medicine,<institution>University of Oulu</institution>, Oulu FI-90014,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff81">Biocenter Oulu,<institution>University of Oulu</institution>, Oulu FI-90014,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name><affiliation wicri:level="1"><nlm:aff id="aff52">Department of Cardiology,<institution>Leiden University Medical Center</institution>, 2300 RC Leiden,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation wicri:level="1"><nlm:aff id="aff19">Institute for Molecular Medicine,<institution>University of Helsinki</institution>, 00290 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff27"><institution>National Institute for Health and Welfare</institution>, 00271 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff30">Department of Public Health,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S." last="Kooner">Jaspal S. Kooner</name><affiliation wicri:level="1"><nlm:aff id="aff61">Department of Cardiology,<institution>Ealing Hospital</institution>, Middlesex UB1 3HW,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff62"><institution>Imperial College Healthcare National Health Service Trust</institution>, London W12 0HS,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff82">Faculty of Medicine, National Heart & Lung Institute, Cardiovascular Science, Hammersmith Hospital,<institution>Imperial College London</institution>, London W12 0NN,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltan" last="Kutalik">Zoltan Kutalik</name><affiliation wicri:level="1"><nlm:aff id="aff83">Institute of Social and Preventive Medicine,<institution>Centre Hospitalier Universitaire Vaudoise</institution>, 1010 Lausanne,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><affiliation wicri:level="1"><nlm:aff id="aff67"><institution>Folkhälsan Research Centre</institution>, Public Health Research, 00290 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff84">Collegium for Advanced Studies,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff85">Institute of Behavioural Sciences,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation wicri:level="1"><nlm:aff id="aff31">Medical Research Council Epidemiology Unit, Institute of Metabolic Science,<institution>University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0QQ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation wicri:level="1"><nlm:aff id="aff32">Department of Clinical Chemistry,<institution>Fimlab Laboratories and University of Tampere School of Medicine</institution>, Tampere 33520,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation><nlm:aff id="aff86">Wake Forest School of Medicine, Department of Epidemiology & Prevention, Public Health Sciences,<institution>Wake Forest School of Medicine</institution>, Winston-Salem,<addr-line>NC</addr-line> 27157;</nlm:aff></affiliation></author><author><name sortKey="Madden, Pamela A F" sort="Madden, Pamela A F" uniqKey="Madden P" first="Pamela A. F." last="Madden">Pamela A. F. Madden</name><affiliation><nlm:aff id="aff87"><institution>Department of Psychiatry, Washington University School of Medicine</institution>, St. Louis,<addr-line>MO</addr-line> 63110;</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas" sort="Martin, Nicholas" uniqKey="Martin N" first="Nicholas" last="Martin">Nicholas Martin</name><affiliation wicri:level="1"><nlm:aff id="aff88">Genetic Epidemiology,<institution>Queensland Institute of Medical Research Berghofer Medical Research Institute</institution>, Herston, Brisbane QLD 4029,<country>Australia</country>;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Morrison, Alanna" sort="Morrison, Alanna" uniqKey="Morrison A" first="Alanna" last="Morrison">Alanna Morrison</name><affiliation><nlm:aff id="aff59">Human Genetics Center,<institution>University of Texas Health Science Center at Houston</institution>, Houston,<addr-line>TX</addr-line> 77225;</nlm:aff></affiliation></author><author><name sortKey="Penninx, Brenda" sort="Penninx, Brenda" uniqKey="Penninx B" first="Brenda" last="Penninx">Brenda Penninx</name><affiliation wicri:level="1"><nlm:aff id="aff37">Department of Psychiatry, Institute for Health and Care Research (EMGO) Institute for Health and Care Research and Neuroscience Campus Amsterdam,<institution>Vrije Universiteit Amsterdam University Medical Center/Geestelijke Gezondheids Zorg (GGZ) inGeest</institution>, 1081 HL Amsterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pirastu, Nicola" sort="Pirastu, Nicola" uniqKey="Pirastu N" first="Nicola" last="Pirastu">Nicola Pirastu</name><affiliation wicri:level="1"><nlm:aff id="aff26">Usher Institute for Population Health Sciences and Informatics,<institution>University of Edinburgh</institution>, Edinburgh EH8 9AG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff58">Department of Medical Sciences,<institution>University of Trieste</institution>, 34149 Trieste,<country>Italy</country>;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Psaty, Bruce" sort="Psaty, Bruce" uniqKey="Psaty B" first="Bruce" last="Psaty">Bruce Psaty</name><affiliation><nlm:aff id="aff29">Cardiovascular Health Research Unit, Department of Medicine,<institution>University of Washington</institution>, Seattle,<addr-line>WA</addr-line> 98101;</nlm:aff></affiliation><affiliation><nlm:aff id="aff89">Department of Epidemiology,<institution>University of Washington</institution>, Seattle,<addr-line>WA</addr-line> 98195;</nlm:aff></affiliation><affiliation><nlm:aff id="aff90">Department of Health Services,<institution>University of Washington</institution>, Seattle,<addr-line>WA</addr-line> 98195;</nlm:aff></affiliation><affiliation><nlm:aff id="aff91">Group Health Cooperative,<institution>Group Health Research Institute</institution>, Seattle,<addr-line>WA</addr-line> 98101;</nlm:aff></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation wicri:level="1"><nlm:aff id="aff92">Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital,<institution>University of Turku</institution>, Turku 20520,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff93">Research Centre of Applied and Preventive Cardiovascular Medicine,<institution>University of Turku</institution>, Turku 20520,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ridker, Paul" sort="Ridker, Paul" uniqKey="Ridker P" first="Paul" last="Ridker">Paul Ridker</name><affiliation><nlm:aff id="aff47">Division of Preventive Medicine,<institution>Brigham and Women’s Hospital</institution>, Boston,<addr-line>MA</addr-line> 02215;</nlm:aff></affiliation><affiliation><nlm:aff id="aff63"><institution>Harvard Medical School</institution>, Boston,<addr-line>MA</addr-line> 02115;</nlm:aff></affiliation></author><author><name sortKey="Rose, Richard" sort="Rose, Richard" uniqKey="Rose R" first="Richard" last="Rose">Richard Rose</name><affiliation><nlm:aff id="aff94">Department of Psychological and Brain Sciences,<institution>Indiana University</institution>, Bloomington,<addr-line>IN</addr-line> 47405;</nlm:aff></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name><affiliation><nlm:aff id="aff95">Institute for Translational Genomics and Population Sciences,<institution>Los Angeles Biomedical Research Institute at Harbor–University of California, Los Angeles Medical Center</institution>, Torrance,<addr-line>CA</addr-line> 90509;</nlm:aff></affiliation></author><author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name><affiliation wicri:level="1"><nlm:aff id="aff41">Department of Cardiovascular Sciences, University of Leicester,<institution>Glenfield Hospital</institution>, Leicester LE3 9QP,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff42">National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit,<institution>Glenfield Hospital</institution>, Leicester LE3 9QP,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation wicri:level="1"><nlm:aff id="aff96">Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine,<institution>Medical University of Graz</institution>, 8010 Graz,<country>Austria</country>;</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><affiliation wicri:level="1"><nlm:aff id="aff33">Department of Twin Research and Genetic Epidemiology,<institution>King’s College</institution>, London SE1 7EH,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stott, David" sort="Stott, David" uniqKey="Stott D" first="David" last="Stott">David Stott</name><affiliation wicri:level="1"><nlm:aff id="aff97">Institute of Cardiovascular and Medical Sciences, Faculty of Medicine,<institution>University of Glasgow</institution>, Glasgow G31 2ER,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Strachan, David" sort="Strachan, David" uniqKey="Strachan D" first="David" last="Strachan">David Strachan</name><affiliation wicri:level="1"><nlm:aff id="aff98">Population Health Research Institute, St. George's,<institution>University of London</institution>, London SW17 0RE,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tzoulaki, Ioanna" sort="Tzoulaki, Ioanna" uniqKey="Tzoulaki I" first="Ioanna" last="Tzoulaki">Ioanna Tzoulaki</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Medical Research Council-Public Health England Centre for Environment and Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff99">Department of Hygiene and Epidemiology,<institution>University of Ioannina Medical School</institution>, 45110 Ioannina,<country>Greece</country>;</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation wicri:level="1"><nlm:aff id="aff56">Department of Cardiology, University Medical Center Groningen,<institution>University of Groningen</institution>, 9700RB Groningen,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff100">Department of Genetics, University Medical Center Groningen,<institution>University of Groningen</institution>, 9700RB Groningen,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff101">Durrer Center for Cardiogenetic Research,<institution>Interuniversity Cardiology Institute of The Netherlands–Netherlands Heart Institute</institution>, 3511GC Utrecht,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="1"><nlm:aff id="aff9">Genetic Epidemiology Unit, Department of Epidemiology,<institution>Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Marques Vidal, Pedro" sort="Marques Vidal, Pedro" uniqKey="Marques Vidal P" first="Pedro" last="Marques-Vidal">Pedro Marques-Vidal</name><affiliation wicri:level="1"><nlm:aff id="aff102">Department of Medicine, Internal Medicine,<institution>Lausanne University Hospital</institution>, 1011 Lausanne,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation wicri:level="1"><nlm:aff id="aff102">Department of Medicine, Internal Medicine,<institution>Lausanne University Hospital</institution>, 1011 Lausanne,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation wicri:level="1"><nlm:aff id="aff48">Medical Research Council Epidemiology Unit,<institution>University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0QQ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B." last="Whitfield">John B. Whitfield</name><affiliation wicri:level="1"><nlm:aff id="aff88">Genetic Epidemiology,<institution>Queensland Institute of Medical Research Berghofer Medical Research Institute</institution>, Herston, Brisbane QLD 4029,<country>Australia</country>;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, James" sort="Wilson, James" uniqKey="Wilson J" first="James" last="Wilson">James Wilson</name><affiliation wicri:level="1"><nlm:aff id="aff26">Usher Institute for Population Health Sciences and Informatics,<institution>University of Edinburgh</institution>, Edinburgh EH8 9AG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff57">Medical Research Council Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh,<institution>Western General Hospital</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wolffenbuttel, Bruce" sort="Wolffenbuttel, Bruce" uniqKey="Wolffenbuttel B" first="Bruce" last="Wolffenbuttel">Bruce Wolffenbuttel</name><affiliation wicri:level="1"><nlm:aff id="aff103">Department of Endocrinology, University Medical Center Groningen,<institution>University of Groningen</institution>, 9700RB Groningen,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bakalkin, Georgy" sort="Bakalkin, Georgy" uniqKey="Bakalkin G" first="Georgy" last="Bakalkin">Georgy Bakalkin</name><affiliation wicri:level="1"><nlm:aff id="aff104">Division of Biological Research on Drug Dependence, Department of Pharmaceutical, Biosciences,<institution>Uppsala University</institution>, 751 24 Uppsala,<country>Sweden</country>;</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Evangelou, Evangelos" sort="Evangelou, Evangelos" uniqKey="Evangelou E" first="Evangelos" last="Evangelou">Evangelos Evangelou</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff99">Department of Hygiene and Epidemiology,<institution>University of Ioannina Medical School</institution>, 45110 Ioannina,<country>Greece</country>;</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yun" sort="Liu, Yun" uniqKey="Liu Y" first="Yun" last="Liu">Yun Liu</name><affiliation wicri:level="1"><nlm:aff id="aff105">Key Laboratory of Metabolism and Molecular Medicine,<institution>Ministry of Education</institution>, 200032 Shanghai,<country>People’s Republic of China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff106">Department of Biochemistry and Molecular Biology,<institution>Fudan University Shanghai Medical College</institution>, 200032 Shanghai,<country>People’s Republic of China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rice, Kenneth M" sort="Rice, Kenneth M" uniqKey="Rice K" first="Kenneth M." last="Rice">Kenneth M. Rice</name><affiliation><nlm:aff id="aff107">Department of Biostatistics,<institution>University of Washington</institution>, Seattle,<addr-line>WA</addr-line> 98195;</nlm:aff></affiliation></author><author><name sortKey="Desrivieres, Sylvane" sort="Desrivieres, Sylvane" uniqKey="Desrivieres S" first="Sylvane" last="Desrivières">Sylvane Desrivières</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council—Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kliewer, Steven A" sort="Kliewer, Steven A" uniqKey="Kliewer S" first="Steven A." last="Kliewer">Steven A. Kliewer</name><affiliation><nlm:aff id="aff7">Department of Pharmacology,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390;</nlm:aff></affiliation><affiliation><nlm:aff id="aff108">Department of Molecular Biology,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390</nlm:aff></affiliation></author><author><name sortKey="Mangelsdorf, David J" sort="Mangelsdorf, David J" uniqKey="Mangelsdorf D" first="David J." last="Mangelsdorf">David J. Mangelsdorf</name><affiliation><nlm:aff id="aff7">Department of Pharmacology,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390;</nlm:aff></affiliation><affiliation><nlm:aff id="aff8"><institution>Howard Hughes Medical Institute</institution>,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390;</nlm:aff></affiliation></author><author><name sortKey="Muller, Christian P" sort="Muller, Christian P" uniqKey="Muller C" first="Christian P." last="Müller">Christian P. Müller</name><affiliation wicri:level="1"><nlm:aff id="aff22">Department of Psychiatry and Psychotherapy,<institution>Friedrich Alexander University Erlangen-Nuremberg</institution>, 91054 Erlangen,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Levy, Daniel" sort="Levy, Daniel" uniqKey="Levy D" first="Daniel" last="Levy">Daniel Levy</name><affiliation><nlm:aff id="aff2"><institution>The Framingham Heart Study</institution>, Framingham,<addr-line>MA</addr-line> 01702;</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">The Population Sciences Branch, Division of Intramural Research,<institution>National Heart, Lung, and Blood Institute</institution>, Bethesda,<addr-line>MD</addr-line> 20824;</nlm:aff></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Medical Research Council-Public Health England Centre for Environment and Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27911795</idno><idno type="pmc">5167198</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167198</idno><idno type="RBID">PMC:5167198</idno><idno type="doi">10.1073/pnas.1611243113</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001C11</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001C11</idno><idno type="wicri:Area/Pmc/Curation">001A69</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001A69</idno><idno type="wicri:Area/Pmc/Checkpoint">000B98</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B98</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001495</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001495</idno><idno type="wicri:Area/PubMed/Curation">001473</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001473</idno><idno type="wicri:Area/PubMed/Checkpoint">001473</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001473</idno><idno type="wicri:Area/Ncbi/Merge">003F77</idno><idno type="wicri:Area/Ncbi/Curation">003F77</idno><idno type="wicri:Area/Ncbi/Checkpoint">003F77</idno><idno type="wicri:Area/Main/Merge">002515</idno><idno type="wicri:Area/Main/Curation">002516</idno><idno type="wicri:Area/Main/Exploration">002516</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>KLB</italic> is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference</title><author><name sortKey="Schumann, Gunter" sort="Schumann, Gunter" uniqKey="Schumann G" first="Gunter" last="Schumann">Gunter Schumann</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council—Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Chunyu" sort="Liu, Chunyu" uniqKey="Liu C" first="Chunyu" last="Liu">Chunyu Liu</name><affiliation><nlm:aff id="aff2"><institution>The Framingham Heart Study</institution>, Framingham,<addr-line>MA</addr-line> 01702;</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">The Population Sciences Branch, Division of Intramural Research,<institution>National Heart, Lung, and Blood Institute</institution>, Bethesda,<addr-line>MD</addr-line> 20824;</nlm:aff></affiliation><affiliation><nlm:aff id="aff4"><institution>Department of Biostatistics, Boston University School of Public Health</institution>, Boston,<addr-line>MA</addr-line> 02118;</nlm:aff></affiliation></author><author><name sortKey="O Eilly, Paul" sort="O Eilly, Paul" uniqKey="O Eilly P" first="Paul" last="O Eilly">Paul O Eilly</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council—Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gao, He" sort="Gao, He" uniqKey="Gao H" first="He" last="Gao">He Gao</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Medical Research Council-Public Health England Centre for Environment and Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Song, Parkyong" sort="Song, Parkyong" uniqKey="Song P" first="Parkyong" last="Song">Parkyong Song</name><affiliation><nlm:aff id="aff7">Department of Pharmacology,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390;</nlm:aff></affiliation><affiliation><nlm:aff id="aff8"><institution>Howard Hughes Medical Institute</institution>,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390;</nlm:aff></affiliation></author><author><name sortKey="Xu, Bing" sort="Xu, Bing" uniqKey="Xu B" first="Bing" last="Xu">Bing Xu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council—Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ruggeri, Barbara" sort="Ruggeri, Barbara" uniqKey="Ruggeri B" first="Barbara" last="Ruggeri">Barbara Ruggeri</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council—Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation wicri:level="1"><nlm:aff id="aff9">Genetic Epidemiology Unit, Department of Epidemiology,<institution>Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jia, Tianye" sort="Jia, Tianye" uniqKey="Jia T" first="Tianye" last="Jia">Tianye Jia</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council—Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Preis, Sarah" sort="Preis, Sarah" uniqKey="Preis S" first="Sarah" last="Preis">Sarah Preis</name><affiliation><nlm:aff id="aff4"><institution>Department of Biostatistics, Boston University School of Public Health</institution>, Boston,<addr-line>MA</addr-line> 02118;</nlm:aff></affiliation></author><author><name sortKey="Segura Lepe, Marcelo" sort="Segura Lepe, Marcelo" uniqKey="Segura Lepe M" first="Marcelo" last="Segura Lepe">Marcelo Segura Lepe</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Section of Bioinformatics, Bayer Pharma AG</institution>, 13342 Berlin,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Akira, Shizuo" sort="Akira, Shizuo" uniqKey="Akira S" first="Shizuo" last="Akira">Shizuo Akira</name><affiliation wicri:level="1"><nlm:aff id="aff11">Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Research Institute for Microbial Diseases,<institution>Osaka University</institution>, Osaka 565-0871,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barbieri, Caterina" sort="Barbieri, Caterina" uniqKey="Barbieri C" first="Caterina" last="Barbieri">Caterina Barbieri</name><affiliation wicri:level="1"><nlm:aff id="aff12">Division of Genetics and Cell Biology,<institution>San Raffaele Research Institute</institution>, 20132 Milan,<country>Italy</country>;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Baumeister, Sebastian" sort="Baumeister, Sebastian" uniqKey="Baumeister S" first="Sebastian" last="Baumeister">Sebastian Baumeister</name><affiliation wicri:level="1"><nlm:aff id="aff13">Institute for Community Medicine,<institution>University Medicine Greifswald</institution>, Greifswald 17475,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff14">Department of Epidemiology and Preventive Medicine,<institution>University of Regensburg</institution>, 93053 Regensburg,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cauchi, Stephane" sort="Cauchi, Stephane" uniqKey="Cauchi S" first="Stephane" last="Cauchi">Stephane Cauchi</name><affiliation wicri:level="1"><nlm:aff id="aff15">CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes,<institution>Lille 2 University</institution>, 59000 Lille,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Clarke, Toni Kim" sort="Clarke, Toni Kim" uniqKey="Clarke T" first="Toni-Kim" last="Clarke">Toni-Kim Clarke</name><affiliation wicri:level="1"><nlm:aff id="aff16">Divison of Psychiatry,<institution>University of Edinburgh</institution>, Edinburgh EH10 5HF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Enroth, Stefan" sort="Enroth, Stefan" uniqKey="Enroth S" first="Stefan" last="Enroth">Stefan Enroth</name><affiliation wicri:level="1"><nlm:aff id="aff17">Science for Life Laboratory, Department of Immunology, Genetics and Pathology,<institution>Uppsala University</institution>, 75108 Uppsala,<country>Sweden</country>;</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name><affiliation wicri:level="1"><nlm:aff id="aff18">Estonian Genome Center,<institution>University of Tartu</institution>, 51010 Tartu,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="H Llfors, Jenni" sort="H Llfors, Jenni" uniqKey="H Llfors J" first="Jenni" last="H Llfors">Jenni H Llfors</name><affiliation wicri:level="1"><nlm:aff id="aff19">Institute for Molecular Medicine,<institution>University of Helsinki</institution>, 00290 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Sarah E" sort="Harris, Sarah E" uniqKey="Harris S" first="Sarah E." last="Harris">Sarah E. Harris</name><affiliation wicri:level="1"><nlm:aff id="aff20">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff21">Centre for Genomic and Experimental Medicine,<institution>University of Edinburgh</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hieber, Saskia" sort="Hieber, Saskia" uniqKey="Hieber S" first="Saskia" last="Hieber">Saskia Hieber</name><affiliation wicri:level="1"><nlm:aff id="aff22">Department of Psychiatry and Psychotherapy,<institution>Friedrich Alexander University Erlangen-Nuremberg</institution>, 91054 Erlangen,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hofer, Edith" sort="Hofer, Edith" uniqKey="Hofer E" first="Edith" last="Hofer">Edith Hofer</name><affiliation wicri:level="1"><nlm:aff id="aff23">Clinical Division of Neurogeriatrics, Department of Neurology,<institution>Medical University Graz</institution>, 8036 Graz,<country>Austria</country>;</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff24">Institute of Medical Informatics, Statistics and Documentation,<institution>Medical University Graz</institution>, 8036 Graz,<country>Austria</country>;</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation wicri:level="1"><nlm:aff id="aff25">Department of Biological Psychology,<institution>Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research</institution>, 1081 BT Amsterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation wicri:level="1"><nlm:aff id="aff17">Science for Life Laboratory, Department of Immunology, Genetics and Pathology,<institution>Uppsala University</institution>, 75108 Uppsala,<country>Sweden</country>;</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Joshi, Peter K" sort="Joshi, Peter K" uniqKey="Joshi P" first="Peter K." last="Joshi">Peter K. Joshi</name><affiliation wicri:level="1"><nlm:aff id="aff26">Usher Institute for Population Health Sciences and Informatics,<institution>University of Edinburgh</institution>, Edinburgh EH8 9AG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kaartinen, Niina" sort="Kaartinen, Niina" uniqKey="Kaartinen N" first="Niina" last="Kaartinen">Niina Kaartinen</name><affiliation wicri:level="1"><nlm:aff id="aff27"><institution>National Institute for Health and Welfare</institution>, 00271 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Laitinen, Jaana" sort="Laitinen, Jaana" uniqKey="Laitinen J" first="Jaana" last="Laitinen">Jaana Laitinen</name><affiliation wicri:level="1"><nlm:aff id="aff28"><institution>Quantified Employee-Unit, Finnish Institute of Occupational Health</institution>, 00250 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lemaitre, Rozenn" sort="Lemaitre, Rozenn" uniqKey="Lemaitre R" first="Rozenn" last="Lemaitre">Rozenn Lemaitre</name><affiliation><nlm:aff id="aff29">Cardiovascular Health Research Unit, Department of Medicine,<institution>University of Washington</institution>, Seattle,<addr-line>WA</addr-line> 98101;</nlm:aff></affiliation></author><author><name sortKey="Loukola, Anu" sort="Loukola, Anu" uniqKey="Loukola A" first="Anu" last="Loukola">Anu Loukola</name><affiliation wicri:level="1"><nlm:aff id="aff19">Institute for Molecular Medicine,<institution>University of Helsinki</institution>, 00290 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff30">Department of Public Health,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Luan, Jian N" sort="Luan, Jian N" uniqKey="Luan J" first="Jian N" last="Luan">Jian N Luan</name><affiliation wicri:level="1"><nlm:aff id="aff31">Medical Research Council Epidemiology Unit, Institute of Metabolic Science,<institution>University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0QQ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name><affiliation wicri:level="1"><nlm:aff id="aff32">Department of Clinical Chemistry,<institution>Fimlab Laboratories and University of Tampere School of Medicine</institution>, Tampere 33520,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation wicri:level="1"><nlm:aff id="aff33">Department of Twin Research and Genetic Epidemiology,<institution>King’s College</institution>, London SE1 7EH,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff34"><institution>National Institute for Health Research Biomedical Research Centre at Guy’s and St. Thomas’ Foundation Trust</institution>, London SE1 9RT, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>, London SE1 9RT</wicri:regionArea><wicri:noRegion>London SE1 9RT</wicri:noRegion></affiliation></author><author><name sortKey="Manichaikul, Ani" sort="Manichaikul, Ani" uniqKey="Manichaikul A" first="Ani" last="Manichaikul">Ani Manichaikul</name><affiliation><nlm:aff id="aff35">Center for Public Health Genomics, Department of Public Health Sciences,<institution>University of Virginia</institution>, Charlottesville,<addr-line>VA</addr-line> 22903;</nlm:aff></affiliation><affiliation><nlm:aff id="aff36">Biostatistics Section, Department of Public Health Sciences,<institution>University of Virginia</institution>, Charlottesville,<addr-line>VA</addr-line> 22903;</nlm:aff></affiliation></author><author><name sortKey="Mbarek, Hamdi" sort="Mbarek, Hamdi" uniqKey="Mbarek H" first="Hamdi" last="Mbarek">Hamdi Mbarek</name><affiliation wicri:level="1"><nlm:aff id="aff25">Department of Biological Psychology,<institution>Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research</institution>, 1081 BT Amsterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Milaneschi, Yuri" sort="Milaneschi, Yuri" uniqKey="Milaneschi Y" first="Yuri" last="Milaneschi">Yuri Milaneschi</name><affiliation wicri:level="1"><nlm:aff id="aff37">Department of Psychiatry, Institute for Health and Care Research (EMGO) Institute for Health and Care Research and Neuroscience Campus Amsterdam,<institution>Vrije Universiteit Amsterdam University Medical Center/Geestelijke Gezondheids Zorg (GGZ) inGeest</institution>, 1081 HL Amsterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Moayyeri, Alireza" sort="Moayyeri, Alireza" uniqKey="Moayyeri A" first="Alireza" last="Moayyeri">Alireza Moayyeri</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff38">Institute of Health Informatics,<institution>University College London</institution>, London NW1 2DA,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff39"><institution>Farr Institute of Health Informatics Research</institution>, University College London Institute of Health Informatics, London NW1 2DA,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mukamal, Kenneth" sort="Mukamal, Kenneth" uniqKey="Mukamal K" first="Kenneth" last="Mukamal">Kenneth Mukamal</name><affiliation><nlm:aff id="aff40">Department of Medicine,<institution>Beth Israel Deaconess Medical Center and Harvard Medical School</institution>, Boston,<addr-line>MA</addr-line> 02215;</nlm:aff></affiliation></author><author><name sortKey="Nelson, Christopher" sort="Nelson, Christopher" uniqKey="Nelson C" first="Christopher" last="Nelson">Christopher Nelson</name><affiliation wicri:level="1"><nlm:aff id="aff41">Department of Cardiovascular Sciences, University of Leicester,<institution>Glenfield Hospital</institution>, Leicester LE3 9QP,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff42">National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit,<institution>Glenfield Hospital</institution>, Leicester LE3 9QP,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nettleton, Jennifer" sort="Nettleton, Jennifer" uniqKey="Nettleton J" first="Jennifer" last="Nettleton">Jennifer Nettleton</name><affiliation><nlm:aff id="aff43">Division of Epidemiology, Human Genetics, and Environmental Sciences,<institution>University of Texas Health Sciences Center</institution>, Houston,<addr-line>TX</addr-line> 77225;</nlm:aff></affiliation></author><author><name sortKey="Partinen, Eemil" sort="Partinen, Eemil" uniqKey="Partinen E" first="Eemil" last="Partinen">Eemil Partinen</name><affiliation wicri:level="1"><nlm:aff id="aff44">Faculty of Medicine,<institution>University of Tartu</institution>, 50411 Tartu,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rawal, Rajesh" sort="Rawal, Rajesh" uniqKey="Rawal R" first="Rajesh" last="Rawal">Rajesh Rawal</name><affiliation wicri:level="1"><nlm:aff id="aff45">Department of Molecular Epidemiology, Institute of Epidemiology II,<institution>Helmholtz Zentrum München</institution>, 85764 Neuherberg,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Robino, Antonietta" sort="Robino, Antonietta" uniqKey="Robino A" first="Antonietta" last="Robino">Antonietta Robino</name><affiliation wicri:level="1"><nlm:aff id="aff46"><institution>Institute for Maternal and Child Health—Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Burlo Garofolo</institution>, 34137 Trieste,<country>Italy</country>;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rose, Lynda" sort="Rose, Lynda" uniqKey="Rose L" first="Lynda" last="Rose">Lynda Rose</name><affiliation><nlm:aff id="aff47">Division of Preventive Medicine,<institution>Brigham and Women’s Hospital</institution>, Boston,<addr-line>MA</addr-line> 02215;</nlm:aff></affiliation></author><author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name><affiliation wicri:level="1"><nlm:aff id="aff12">Division of Genetics and Cell Biology,<institution>San Raffaele Research Institute</institution>, 20132 Milan,<country>Italy</country>;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Satoh, Takashi" sort="Satoh, Takashi" uniqKey="Satoh T" first="Takashi" last="Satoh">Takashi Satoh</name><affiliation wicri:level="1"><nlm:aff id="aff11">Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Research Institute for Microbial Diseases,<institution>Osaka University</institution>, Osaka 565-0871,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation wicri:level="1"><nlm:aff id="aff23">Clinical Division of Neurogeriatrics, Department of Neurology,<institution>Medical University Graz</institution>, 8036 Graz,<country>Austria</country>;</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schraut, Katharina" sort="Schraut, Katharina" uniqKey="Schraut K" first="Katharina" last="Schraut">Katharina Schraut</name><affiliation wicri:level="1"><nlm:aff id="aff26">Usher Institute for Population Health Sciences and Informatics,<institution>University of Edinburgh</institution>, Edinburgh EH8 9AG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Scott, Robert" sort="Scott, Robert" uniqKey="Scott R" first="Robert" last="Scott">Robert Scott</name><affiliation wicri:level="1"><nlm:aff id="aff48">Medical Research Council Epidemiology Unit,<institution>University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0QQ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name><affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Research Institute, Icelandic Heart Association</institution>, 201 Kopavogur,<country>Iceland</country>;</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><affiliation wicri:level="1"><nlm:aff id="aff20">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff50">Alzheimer Scotland Research Centre,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation wicri:level="1"><nlm:aff id="aff13">Institute for Community Medicine,<institution>University Medicine Greifswald</institution>, Greifswald 17475,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff51">Interfaculty Institute for Genetics and Functional Genomics,<institution>University Medicine Greifswald</institution>, 17475 Greifswald,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name><affiliation wicri:level="1"><nlm:aff id="aff52">Department of Cardiology,<institution>Leiden University Medical Center</institution>, 2300 RC Leiden,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff53">Department of Gerontology and Geriatrics,<institution>Leiden University Medical Center</institution>, 2300 RC Leiden,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G." last="Uitterlinden">André G. Uitterlinden</name><affiliation wicri:level="1"><nlm:aff id="aff54">Department of internal Medicine,<institution>Erasmus Medical Center</institution>, 3015 CN Rotterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff55">Department of Epidemiology,<institution>Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Venturini, Cristina" sort="Venturini, Cristina" uniqKey="Venturini C" first="Cristina" last="Venturini">Cristina Venturini</name><affiliation wicri:level="1"><nlm:aff id="aff33">Department of Twin Research and Genetic Epidemiology,<institution>King’s College</institution>, London SE1 7EH,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vergnaud, Anne Claire" sort="Vergnaud, Anne Claire" uniqKey="Vergnaud A" first="Anne-Claire" last="Vergnaud">Anne-Claire Vergnaud</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name><affiliation wicri:level="1"><nlm:aff id="aff56">Department of Cardiology, University Medical Center Groningen,<institution>University of Groningen</institution>, 9700RB Groningen,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation wicri:level="1"><nlm:aff id="aff57">Medical Research Council Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh,<institution>Western General Hospital</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vuckovic, Dragana" sort="Vuckovic, Dragana" uniqKey="Vuckovic D" first="Dragana" last="Vuckovic">Dragana Vuckovic</name><affiliation wicri:level="1"><nlm:aff id="aff58">Department of Medical Sciences,<institution>University of Trieste</institution>, 34149 Trieste,<country>Italy</country>;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wedenoja, Juho" sort="Wedenoja, Juho" uniqKey="Wedenoja J" first="Juho" last="Wedenoja">Juho Wedenoja</name><affiliation wicri:level="1"><nlm:aff id="aff30">Department of Public Health,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yengo, Loic" sort="Yengo, Loic" uniqKey="Yengo L" first="Loic" last="Yengo">Loic Yengo</name><affiliation wicri:level="1"><nlm:aff id="aff15">CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes,<institution>Lille 2 University</institution>, 59000 Lille,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yu, Bing" sort="Yu, Bing" uniqKey="Yu B" first="Bing" last="Yu">Bing Yu</name><affiliation><nlm:aff id="aff59">Human Genetics Center,<institution>University of Texas Health Science Center at Houston</institution>, Houston,<addr-line>TX</addr-line> 77225;</nlm:aff></affiliation><affiliation><nlm:aff id="aff60">Division of Epidemiology,<institution>University of Texas Health Science Center at Houston</institution>, Houston,<addr-line>TX</addr-line> 77225;</nlm:aff></affiliation></author><author><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff61">Department of Cardiology,<institution>Ealing Hospital</institution>, Middlesex UB1 3HW,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation wicri:level="1"><nlm:aff id="aff48">Medical Research Council Epidemiology Unit,<institution>University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0QQ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation wicri:level="1"><nlm:aff id="aff25">Department of Biological Psychology,<institution>Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research</institution>, 1081 BT Amsterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chambers, John" sort="Chambers, John" uniqKey="Chambers J" first="John" last="Chambers">John Chambers</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff61">Department of Cardiology,<institution>Ealing Hospital</institution>, Middlesex UB1 3HW,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff62"><institution>Imperial College Healthcare National Health Service Trust</institution>, London W12 0HS,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name><affiliation><nlm:aff id="aff47">Division of Preventive Medicine,<institution>Brigham and Women’s Hospital</institution>, Boston,<addr-line>MA</addr-line> 02215;</nlm:aff></affiliation><affiliation><nlm:aff id="aff63"><institution>Harvard Medical School</institution>, Boston,<addr-line>MA</addr-line> 02115;</nlm:aff></affiliation></author><author><name sortKey="Daniela, Toniolo" sort="Daniela, Toniolo" uniqKey="Daniela T" first="Toniolo" last="Daniela">Toniolo Daniela</name><affiliation wicri:level="1"><nlm:aff id="aff12">Division of Genetics and Cell Biology,<institution>San Raffaele Research Institute</institution>, 20132 Milan,<country>Italy</country>;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Geus, Eco" sort="De Geus, Eco" uniqKey="De Geus E" first="Eco" last="De Geus">Eco De Geus</name><affiliation wicri:level="1"><nlm:aff id="aff25">Department of Biological Psychology,<institution>Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research</institution>, 1081 BT Amsterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deary, Ian" sort="Deary, Ian" uniqKey="Deary I" first="Ian" last="Deary">Ian Deary</name><affiliation wicri:level="1"><nlm:aff id="aff20">Centre for Cognitive Ageing and Cognitive Epidemiology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff64">Psychology,<institution>University of Edinburgh</institution>, Edinburgh EH8 9JZ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G." last="Eriksson">Johan G. Eriksson</name><affiliation wicri:level="1"><nlm:aff id="aff27"><institution>National Institute for Health and Welfare</institution>, 00271 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff65">Department of General Practice and Primary Health Care,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff66">Unit of General Practice,<institution>Helsinki University Central Hospital</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff67"><institution>Folkhälsan Research Centre</institution>, Public Health Research, 00290 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff68"><institution>Vasa Central Hospital</institution>, 65130 Vasa,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation wicri:level="1"><nlm:aff id="aff18">Estonian Genome Center,<institution>University of Tartu</institution>, 51010 Tartu,<country>Estonia</country>;</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eulenburg, Volker" sort="Eulenburg, Volker" uniqKey="Eulenburg V" first="Volker" last="Eulenburg">Volker Eulenburg</name><affiliation wicri:level="1"><nlm:aff id="aff69">Institute for Biochemistry and Molecular Medicine,<institution>Friedrich Alexander University Erlangen-Nuremberg</institution>, 91054 Erlangen,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H." last="Franco">Oscar H. Franco</name><affiliation wicri:level="1"><nlm:aff id="aff55">Department of Epidemiology,<institution>Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation wicri:level="1"><nlm:aff id="aff15">CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes,<institution>Lille 2 University</institution>, 59000 Lille,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff70">Department of Genomics of Common Disease, School of Public Health,<institution>Imperial College London</institution>, London W12 0HR,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation wicri:level="1"><nlm:aff id="aff45">Department of Molecular Epidemiology, Institute of Epidemiology II,<institution>Helmholtz Zentrum München</institution>, 85764 Neuherberg,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Grabe, Hans J" sort="Grabe, Hans J" uniqKey="Grabe H" first="Hans J." last="Grabe">Hans J. Grabe</name><affiliation wicri:level="1"><nlm:aff id="aff71">Department of Psychiatry and Psychotherapy,<institution>University Medicine Greifswald</institution>, 17475 Greifswald,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Research Institute, Icelandic Heart Association</institution>, 201 Kopavogur,<country>Iceland</country>;</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff72">Faculty of Medicine,<institution>University of Iceland</institution>, 101 Reykjavik,<country>Iceland</country>;</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation wicri:level="1"><nlm:aff id="aff17">Science for Life Laboratory, Department of Immunology, Genetics and Pathology,<institution>Uppsala University</institution>, 75108 Uppsala,<country>Sweden</country>;</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="aff73">National Institute on Aging,<institution>NIH</institution>, Bethesda,<addr-line>MD</addr-line> 20892;</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation wicri:level="1"><nlm:aff id="aff74">Department of Obstetrics and Gynecology,<institution>Oulu University Hospital</institution>, 90029 Oulu,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff75">Medical Research Center,<institution>University of Oulu</institution>, 90014 Oulu,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff76">Unit of Primary Care,<institution>Oulu University Hospital</institution>, 90220 Oulu,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Heath, Andrew C" sort="Heath, Andrew C" uniqKey="Heath A" first="Andrew C." last="Heath">Andrew C. Heath</name><affiliation><nlm:aff id="aff77">Department of Psychiatry,<institution>Washington University School of Medicine in St. Louis</institution>, St. Louis,<addr-line>MO</addr-line> 63110;</nlm:aff></affiliation></author><author><name sortKey="Hocking, Lynne" sort="Hocking, Lynne" uniqKey="Hocking L" first="Lynne" last="Hocking">Lynne Hocking</name><affiliation wicri:level="1"><nlm:aff id="aff78">Institute of Medical Sciences,<institution>University of Aberdeen</institution>, Aberdeen AB25 2ZD,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><nlm:aff id="aff55">Department of Epidemiology,<institution>Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huth, Cornelia" sort="Huth, Cornelia" uniqKey="Huth C" first="Cornelia" last="Huth">Cornelia Huth</name><affiliation wicri:level="1"><nlm:aff id="aff79">Institute of Epidemiology II, Helmholtz Zentrum München,<institution>German Research Center for Environmental Health GmbH</institution>, D-85764 Neuherberg,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff76">Unit of Primary Care,<institution>Oulu University Hospital</institution>, 90220 Oulu,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff80">Center for Life Course Epidemiology, Faculty of Medicine,<institution>University of Oulu</institution>, Oulu FI-90014,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff81">Biocenter Oulu,<institution>University of Oulu</institution>, Oulu FI-90014,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name><affiliation wicri:level="1"><nlm:aff id="aff52">Department of Cardiology,<institution>Leiden University Medical Center</institution>, 2300 RC Leiden,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation wicri:level="1"><nlm:aff id="aff19">Institute for Molecular Medicine,<institution>University of Helsinki</institution>, 00290 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff27"><institution>National Institute for Health and Welfare</institution>, 00271 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff30">Department of Public Health,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S." last="Kooner">Jaspal S. Kooner</name><affiliation wicri:level="1"><nlm:aff id="aff61">Department of Cardiology,<institution>Ealing Hospital</institution>, Middlesex UB1 3HW,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff62"><institution>Imperial College Healthcare National Health Service Trust</institution>, London W12 0HS,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff82">Faculty of Medicine, National Heart & Lung Institute, Cardiovascular Science, Hammersmith Hospital,<institution>Imperial College London</institution>, London W12 0NN,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltan" last="Kutalik">Zoltan Kutalik</name><affiliation wicri:level="1"><nlm:aff id="aff83">Institute of Social and Preventive Medicine,<institution>Centre Hospitalier Universitaire Vaudoise</institution>, 1010 Lausanne,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><affiliation wicri:level="1"><nlm:aff id="aff67"><institution>Folkhälsan Research Centre</institution>, Public Health Research, 00290 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff84">Collegium for Advanced Studies,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff85">Institute of Behavioural Sciences,<institution>University of Helsinki</institution>, 00014 Helsinki,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation wicri:level="1"><nlm:aff id="aff31">Medical Research Council Epidemiology Unit, Institute of Metabolic Science,<institution>University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0QQ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation wicri:level="1"><nlm:aff id="aff32">Department of Clinical Chemistry,<institution>Fimlab Laboratories and University of Tampere School of Medicine</institution>, Tampere 33520,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation><nlm:aff id="aff86">Wake Forest School of Medicine, Department of Epidemiology & Prevention, Public Health Sciences,<institution>Wake Forest School of Medicine</institution>, Winston-Salem,<addr-line>NC</addr-line> 27157;</nlm:aff></affiliation></author><author><name sortKey="Madden, Pamela A F" sort="Madden, Pamela A F" uniqKey="Madden P" first="Pamela A. F." last="Madden">Pamela A. F. Madden</name><affiliation><nlm:aff id="aff87"><institution>Department of Psychiatry, Washington University School of Medicine</institution>, St. Louis,<addr-line>MO</addr-line> 63110;</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas" sort="Martin, Nicholas" uniqKey="Martin N" first="Nicholas" last="Martin">Nicholas Martin</name><affiliation wicri:level="1"><nlm:aff id="aff88">Genetic Epidemiology,<institution>Queensland Institute of Medical Research Berghofer Medical Research Institute</institution>, Herston, Brisbane QLD 4029,<country>Australia</country>;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Morrison, Alanna" sort="Morrison, Alanna" uniqKey="Morrison A" first="Alanna" last="Morrison">Alanna Morrison</name><affiliation><nlm:aff id="aff59">Human Genetics Center,<institution>University of Texas Health Science Center at Houston</institution>, Houston,<addr-line>TX</addr-line> 77225;</nlm:aff></affiliation></author><author><name sortKey="Penninx, Brenda" sort="Penninx, Brenda" uniqKey="Penninx B" first="Brenda" last="Penninx">Brenda Penninx</name><affiliation wicri:level="1"><nlm:aff id="aff37">Department of Psychiatry, Institute for Health and Care Research (EMGO) Institute for Health and Care Research and Neuroscience Campus Amsterdam,<institution>Vrije Universiteit Amsterdam University Medical Center/Geestelijke Gezondheids Zorg (GGZ) inGeest</institution>, 1081 HL Amsterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pirastu, Nicola" sort="Pirastu, Nicola" uniqKey="Pirastu N" first="Nicola" last="Pirastu">Nicola Pirastu</name><affiliation wicri:level="1"><nlm:aff id="aff26">Usher Institute for Population Health Sciences and Informatics,<institution>University of Edinburgh</institution>, Edinburgh EH8 9AG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff58">Department of Medical Sciences,<institution>University of Trieste</institution>, 34149 Trieste,<country>Italy</country>;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Psaty, Bruce" sort="Psaty, Bruce" uniqKey="Psaty B" first="Bruce" last="Psaty">Bruce Psaty</name><affiliation><nlm:aff id="aff29">Cardiovascular Health Research Unit, Department of Medicine,<institution>University of Washington</institution>, Seattle,<addr-line>WA</addr-line> 98101;</nlm:aff></affiliation><affiliation><nlm:aff id="aff89">Department of Epidemiology,<institution>University of Washington</institution>, Seattle,<addr-line>WA</addr-line> 98195;</nlm:aff></affiliation><affiliation><nlm:aff id="aff90">Department of Health Services,<institution>University of Washington</institution>, Seattle,<addr-line>WA</addr-line> 98195;</nlm:aff></affiliation><affiliation><nlm:aff id="aff91">Group Health Cooperative,<institution>Group Health Research Institute</institution>, Seattle,<addr-line>WA</addr-line> 98101;</nlm:aff></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation wicri:level="1"><nlm:aff id="aff92">Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital,<institution>University of Turku</institution>, Turku 20520,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff93">Research Centre of Applied and Preventive Cardiovascular Medicine,<institution>University of Turku</institution>, Turku 20520,<country>Finland</country>;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ridker, Paul" sort="Ridker, Paul" uniqKey="Ridker P" first="Paul" last="Ridker">Paul Ridker</name><affiliation><nlm:aff id="aff47">Division of Preventive Medicine,<institution>Brigham and Women’s Hospital</institution>, Boston,<addr-line>MA</addr-line> 02215;</nlm:aff></affiliation><affiliation><nlm:aff id="aff63"><institution>Harvard Medical School</institution>, Boston,<addr-line>MA</addr-line> 02115;</nlm:aff></affiliation></author><author><name sortKey="Rose, Richard" sort="Rose, Richard" uniqKey="Rose R" first="Richard" last="Rose">Richard Rose</name><affiliation><nlm:aff id="aff94">Department of Psychological and Brain Sciences,<institution>Indiana University</institution>, Bloomington,<addr-line>IN</addr-line> 47405;</nlm:aff></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name><affiliation><nlm:aff id="aff95">Institute for Translational Genomics and Population Sciences,<institution>Los Angeles Biomedical Research Institute at Harbor–University of California, Los Angeles Medical Center</institution>, Torrance,<addr-line>CA</addr-line> 90509;</nlm:aff></affiliation></author><author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name><affiliation wicri:level="1"><nlm:aff id="aff41">Department of Cardiovascular Sciences, University of Leicester,<institution>Glenfield Hospital</institution>, Leicester LE3 9QP,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff42">National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit,<institution>Glenfield Hospital</institution>, Leicester LE3 9QP,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation wicri:level="1"><nlm:aff id="aff96">Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine,<institution>Medical University of Graz</institution>, 8010 Graz,<country>Austria</country>;</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><affiliation wicri:level="1"><nlm:aff id="aff33">Department of Twin Research and Genetic Epidemiology,<institution>King’s College</institution>, London SE1 7EH,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stott, David" sort="Stott, David" uniqKey="Stott D" first="David" last="Stott">David Stott</name><affiliation wicri:level="1"><nlm:aff id="aff97">Institute of Cardiovascular and Medical Sciences, Faculty of Medicine,<institution>University of Glasgow</institution>, Glasgow G31 2ER,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Strachan, David" sort="Strachan, David" uniqKey="Strachan D" first="David" last="Strachan">David Strachan</name><affiliation wicri:level="1"><nlm:aff id="aff98">Population Health Research Institute, St. George's,<institution>University of London</institution>, London SW17 0RE,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tzoulaki, Ioanna" sort="Tzoulaki, Ioanna" uniqKey="Tzoulaki I" first="Ioanna" last="Tzoulaki">Ioanna Tzoulaki</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Medical Research Council-Public Health England Centre for Environment and Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff99">Department of Hygiene and Epidemiology,<institution>University of Ioannina Medical School</institution>, 45110 Ioannina,<country>Greece</country>;</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation wicri:level="1"><nlm:aff id="aff56">Department of Cardiology, University Medical Center Groningen,<institution>University of Groningen</institution>, 9700RB Groningen,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff100">Department of Genetics, University Medical Center Groningen,<institution>University of Groningen</institution>, 9700RB Groningen,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff101">Durrer Center for Cardiogenetic Research,<institution>Interuniversity Cardiology Institute of The Netherlands–Netherlands Heart Institute</institution>, 3511GC Utrecht,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="1"><nlm:aff id="aff9">Genetic Epidemiology Unit, Department of Epidemiology,<institution>Erasmus Medical Center</institution>, 3000 CA Rotterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Marques Vidal, Pedro" sort="Marques Vidal, Pedro" uniqKey="Marques Vidal P" first="Pedro" last="Marques-Vidal">Pedro Marques-Vidal</name><affiliation wicri:level="1"><nlm:aff id="aff102">Department of Medicine, Internal Medicine,<institution>Lausanne University Hospital</institution>, 1011 Lausanne,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation wicri:level="1"><nlm:aff id="aff102">Department of Medicine, Internal Medicine,<institution>Lausanne University Hospital</institution>, 1011 Lausanne,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation wicri:level="1"><nlm:aff id="aff48">Medical Research Council Epidemiology Unit,<institution>University of Cambridge School of Clinical Medicine</institution>, Cambridge CB2 0QQ,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B." last="Whitfield">John B. Whitfield</name><affiliation wicri:level="1"><nlm:aff id="aff88">Genetic Epidemiology,<institution>Queensland Institute of Medical Research Berghofer Medical Research Institute</institution>, Herston, Brisbane QLD 4029,<country>Australia</country>;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, James" sort="Wilson, James" uniqKey="Wilson J" first="James" last="Wilson">James Wilson</name><affiliation wicri:level="1"><nlm:aff id="aff26">Usher Institute for Population Health Sciences and Informatics,<institution>University of Edinburgh</institution>, Edinburgh EH8 9AG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff57">Medical Research Council Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh,<institution>Western General Hospital</institution>, Edinburgh EH4 2XU,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wolffenbuttel, Bruce" sort="Wolffenbuttel, Bruce" uniqKey="Wolffenbuttel B" first="Bruce" last="Wolffenbuttel">Bruce Wolffenbuttel</name><affiliation wicri:level="1"><nlm:aff id="aff103">Department of Endocrinology, University Medical Center Groningen,<institution>University of Groningen</institution>, 9700RB Groningen,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bakalkin, Georgy" sort="Bakalkin, Georgy" uniqKey="Bakalkin G" first="Georgy" last="Bakalkin">Georgy Bakalkin</name><affiliation wicri:level="1"><nlm:aff id="aff104">Division of Biological Research on Drug Dependence, Department of Pharmaceutical, Biosciences,<institution>Uppsala University</institution>, 751 24 Uppsala,<country>Sweden</country>;</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Evangelou, Evangelos" sort="Evangelou, Evangelos" uniqKey="Evangelou E" first="Evangelos" last="Evangelou">Evangelos Evangelou</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff99">Department of Hygiene and Epidemiology,<institution>University of Ioannina Medical School</institution>, 45110 Ioannina,<country>Greece</country>;</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yun" sort="Liu, Yun" uniqKey="Liu Y" first="Yun" last="Liu">Yun Liu</name><affiliation wicri:level="1"><nlm:aff id="aff105">Key Laboratory of Metabolism and Molecular Medicine,<institution>Ministry of Education</institution>, 200032 Shanghai,<country>People’s Republic of China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff106">Department of Biochemistry and Molecular Biology,<institution>Fudan University Shanghai Medical College</institution>, 200032 Shanghai,<country>People’s Republic of China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rice, Kenneth M" sort="Rice, Kenneth M" uniqKey="Rice K" first="Kenneth M." last="Rice">Kenneth M. Rice</name><affiliation><nlm:aff id="aff107">Department of Biostatistics,<institution>University of Washington</institution>, Seattle,<addr-line>WA</addr-line> 98195;</nlm:aff></affiliation></author><author><name sortKey="Desrivieres, Sylvane" sort="Desrivieres, Sylvane" uniqKey="Desrivieres S" first="Sylvane" last="Desrivières">Sylvane Desrivières</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Research Council—Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London SE5 8AF,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kliewer, Steven A" sort="Kliewer, Steven A" uniqKey="Kliewer S" first="Steven A." last="Kliewer">Steven A. Kliewer</name><affiliation><nlm:aff id="aff7">Department of Pharmacology,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390;</nlm:aff></affiliation><affiliation><nlm:aff id="aff108">Department of Molecular Biology,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390</nlm:aff></affiliation></author><author><name sortKey="Mangelsdorf, David J" sort="Mangelsdorf, David J" uniqKey="Mangelsdorf D" first="David J." last="Mangelsdorf">David J. Mangelsdorf</name><affiliation><nlm:aff id="aff7">Department of Pharmacology,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390;</nlm:aff></affiliation><affiliation><nlm:aff id="aff8"><institution>Howard Hughes Medical Institute</institution>,<institution>University of Texas Southwestern Medical Center</institution>, Dallas,<addr-line>TX</addr-line> 75390;</nlm:aff></affiliation></author><author><name sortKey="Muller, Christian P" sort="Muller, Christian P" uniqKey="Muller C" first="Christian P." last="Müller">Christian P. Müller</name><affiliation wicri:level="1"><nlm:aff id="aff22">Department of Psychiatry and Psychotherapy,<institution>Friedrich Alexander University Erlangen-Nuremberg</institution>, 91054 Erlangen,<country>Germany</country>;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Levy, Daniel" sort="Levy, Daniel" uniqKey="Levy D" first="Daniel" last="Levy">Daniel Levy</name><affiliation><nlm:aff id="aff2"><institution>The Framingham Heart Study</institution>, Framingham,<addr-line>MA</addr-line> 01702;</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">The Population Sciences Branch, Division of Intramural Research,<institution>National Heart, Lung, and Blood Institute</institution>, Bethesda,<addr-line>MD</addr-line> 20824;</nlm:aff></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Epidemiology and Biostatistics, School of Public Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Medical Research Council-Public Health England Centre for Environment and Health,<institution>Imperial College London</institution>, London W2 1PG,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Significance</title><p>Alcohol is a widely consumed drug in western societies that can lead to addiction. A small shift in consumption can have dramatic consequences on public health. We performed the largest genome-wide association metaanalysis and replication study to date (>105,000 individuals) and identified a genetic basis for alcohol consumption during nonaddictive drinking. We found that a locus in the gene encoding β-Klotho is associated with alcohol consumption. β-Klotho is an essential receptor component for the endocrine FGFs, FGF19 and FGF21. Using mouse models and pharmacologic administration of FGF21, we show that β-Klotho in the brain controls alcohol drinking. These findings reveal a mechanism regulating alcohol consumption in humans that may be pharmacologically tractable for reducing alcohol intake.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Estonie</li><li>Finlande</li><li>France</li><li>Grèce</li><li>Islande</li><li>Italie</li><li>Japon</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>République populaire de Chine</li><li>Suisse</li><li>Suède</li></country></list><tree><noCountry><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><name sortKey="Heath, Andrew C" sort="Heath, Andrew C" uniqKey="Heath A" first="Andrew C." last="Heath">Andrew C. Heath</name><name sortKey="Kliewer, Steven A" sort="Kliewer, Steven A" uniqKey="Kliewer S" first="Steven A." last="Kliewer">Steven A. Kliewer</name><name sortKey="Lemaitre, Rozenn" sort="Lemaitre, Rozenn" uniqKey="Lemaitre R" first="Rozenn" last="Lemaitre">Rozenn Lemaitre</name><name sortKey="Levy, Daniel" sort="Levy, Daniel" uniqKey="Levy D" first="Daniel" last="Levy">Daniel Levy</name><name sortKey="Liu, Chunyu" sort="Liu, Chunyu" uniqKey="Liu C" first="Chunyu" last="Liu">Chunyu Liu</name><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><name sortKey="Madden, Pamela A F" sort="Madden, Pamela A F" uniqKey="Madden P" first="Pamela A. F." last="Madden">Pamela A. F. Madden</name><name sortKey="Mangelsdorf, David J" sort="Mangelsdorf, David J" uniqKey="Mangelsdorf D" first="David J." last="Mangelsdorf">David J. Mangelsdorf</name><name sortKey="Manichaikul, Ani" sort="Manichaikul, Ani" uniqKey="Manichaikul A" first="Ani" last="Manichaikul">Ani Manichaikul</name><name sortKey="Morrison, Alanna" sort="Morrison, Alanna" uniqKey="Morrison A" first="Alanna" last="Morrison">Alanna Morrison</name><name sortKey="Mukamal, Kenneth" sort="Mukamal, Kenneth" uniqKey="Mukamal K" first="Kenneth" last="Mukamal">Kenneth Mukamal</name><name sortKey="Nettleton, Jennifer" sort="Nettleton, Jennifer" uniqKey="Nettleton J" first="Jennifer" last="Nettleton">Jennifer Nettleton</name><name sortKey="Preis, Sarah" sort="Preis, Sarah" uniqKey="Preis S" first="Sarah" last="Preis">Sarah Preis</name><name sortKey="Psaty, Bruce" sort="Psaty, Bruce" uniqKey="Psaty B" first="Bruce" last="Psaty">Bruce Psaty</name><name sortKey="Rice, Kenneth M" sort="Rice, Kenneth M" uniqKey="Rice K" first="Kenneth M." last="Rice">Kenneth M. Rice</name><name sortKey="Ridker, Paul" sort="Ridker, Paul" uniqKey="Ridker P" first="Paul" last="Ridker">Paul Ridker</name><name sortKey="Rose, Lynda" sort="Rose, Lynda" uniqKey="Rose L" first="Lynda" last="Rose">Lynda Rose</name><name sortKey="Rose, Richard" sort="Rose, Richard" uniqKey="Rose R" first="Richard" last="Rose">Richard Rose</name><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name><name sortKey="Song, Parkyong" sort="Song, Parkyong" uniqKey="Song P" first="Parkyong" last="Song">Parkyong Song</name><name sortKey="Yu, Bing" sort="Yu, Bing" uniqKey="Yu B" first="Bing" last="Yu">Bing Yu</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Schumann, Gunter" sort="Schumann, Gunter" uniqKey="Schumann G" first="Gunter" last="Schumann">Gunter Schumann</name></noRegion><name sortKey="Chambers, John" sort="Chambers, John" uniqKey="Chambers J" first="John" last="Chambers">John Chambers</name><name sortKey="Chambers, John" sort="Chambers, John" uniqKey="Chambers J" first="John" last="Chambers">John Chambers</name><name sortKey="Chambers, John" sort="Chambers, John" uniqKey="Chambers J" first="John" last="Chambers">John Chambers</name><name sortKey="Clarke, Toni Kim" sort="Clarke, Toni Kim" uniqKey="Clarke T" first="Toni-Kim" last="Clarke">Toni-Kim Clarke</name><name sortKey="Deary, Ian" sort="Deary, Ian" uniqKey="Deary I" first="Ian" last="Deary">Ian Deary</name><name sortKey="Deary, Ian" sort="Deary, Ian" uniqKey="Deary I" first="Ian" last="Deary">Ian Deary</name><name sortKey="Desrivieres, Sylvane" sort="Desrivieres, Sylvane" uniqKey="Desrivieres S" first="Sylvane" last="Desrivières">Sylvane Desrivières</name><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><name sortKey="Evangelou, Evangelos" sort="Evangelou, Evangelos" uniqKey="Evangelou E" first="Evangelos" last="Evangelou">Evangelos Evangelou</name><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><name sortKey="Gao, He" sort="Gao, He" uniqKey="Gao H" first="He" last="Gao">He Gao</name><name sortKey="Gao, He" sort="Gao, He" uniqKey="Gao H" first="He" last="Gao">He Gao</name><name sortKey="Harris, Sarah E" sort="Harris, Sarah E" uniqKey="Harris S" first="Sarah E." last="Harris">Sarah E. Harris</name><name sortKey="Harris, Sarah E" sort="Harris, Sarah E" uniqKey="Harris S" first="Sarah E." last="Harris">Sarah E. Harris</name><name sortKey="Hocking, Lynne" sort="Hocking, Lynne" uniqKey="Hocking L" first="Lynne" last="Hocking">Lynne Hocking</name><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><name sortKey="Jia, Tianye" sort="Jia, Tianye" uniqKey="Jia T" first="Tianye" last="Jia">Tianye Jia</name><name sortKey="Joshi, Peter K" sort="Joshi, Peter K" uniqKey="Joshi P" first="Peter K." last="Joshi">Peter K. Joshi</name><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S." last="Kooner">Jaspal S. Kooner</name><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S." last="Kooner">Jaspal S. Kooner</name><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S." last="Kooner">Jaspal S. Kooner</name><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><name sortKey="Luan, Jian N" sort="Luan, Jian N" uniqKey="Luan J" first="Jian N" last="Luan">Jian N Luan</name><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><name sortKey="Moayyeri, Alireza" sort="Moayyeri, Alireza" uniqKey="Moayyeri A" first="Alireza" last="Moayyeri">Alireza Moayyeri</name><name sortKey="Moayyeri, Alireza" sort="Moayyeri, Alireza" uniqKey="Moayyeri A" first="Alireza" last="Moayyeri">Alireza Moayyeri</name><name sortKey="Moayyeri, Alireza" sort="Moayyeri, Alireza" uniqKey="Moayyeri A" first="Alireza" last="Moayyeri">Alireza Moayyeri</name><name sortKey="Nelson, Christopher" sort="Nelson, Christopher" uniqKey="Nelson C" first="Christopher" last="Nelson">Christopher Nelson</name><name sortKey="Nelson, Christopher" sort="Nelson, Christopher" uniqKey="Nelson C" first="Christopher" last="Nelson">Christopher Nelson</name><name sortKey="O Eilly, Paul" sort="O Eilly, Paul" uniqKey="O Eilly P" first="Paul" last="O Eilly">Paul O Eilly</name><name sortKey="Pirastu, Nicola" sort="Pirastu, Nicola" uniqKey="Pirastu N" first="Nicola" last="Pirastu">Nicola Pirastu</name><name sortKey="Ruggeri, Barbara" sort="Ruggeri, Barbara" uniqKey="Ruggeri B" first="Barbara" last="Ruggeri">Barbara Ruggeri</name><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name><name sortKey="Schraut, Katharina" sort="Schraut, Katharina" uniqKey="Schraut K" first="Katharina" last="Schraut">Katharina Schraut</name><name sortKey="Scott, Robert" sort="Scott, Robert" uniqKey="Scott R" first="Robert" last="Scott">Robert Scott</name><name sortKey="Segura Lepe, Marcelo" sort="Segura Lepe, Marcelo" uniqKey="Segura Lepe M" first="Marcelo" last="Segura Lepe">Marcelo Segura Lepe</name><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><name sortKey="Stott, David" sort="Stott, David" uniqKey="Stott D" first="David" last="Stott">David Stott</name><name sortKey="Strachan, David" sort="Strachan, David" uniqKey="Strachan D" first="David" last="Strachan">David Strachan</name><name sortKey="Tzoulaki, Ioanna" sort="Tzoulaki, Ioanna" uniqKey="Tzoulaki I" first="Ioanna" last="Tzoulaki">Ioanna Tzoulaki</name><name sortKey="Tzoulaki, Ioanna" sort="Tzoulaki, Ioanna" uniqKey="Tzoulaki I" first="Ioanna" last="Tzoulaki">Ioanna Tzoulaki</name><name sortKey="Venturini, Cristina" sort="Venturini, Cristina" uniqKey="Venturini C" first="Cristina" last="Venturini">Cristina Venturini</name><name sortKey="Vergnaud, Anne Claire" sort="Vergnaud, Anne Claire" uniqKey="Vergnaud A" first="Anne-Claire" last="Vergnaud">Anne-Claire Vergnaud</name><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><name sortKey="Wilson, James" sort="Wilson, James" uniqKey="Wilson J" first="James" last="Wilson">James Wilson</name><name sortKey="Wilson, James" sort="Wilson, James" uniqKey="Wilson J" first="James" last="Wilson">James Wilson</name><name sortKey="Xu, Bing" sort="Xu, Bing" uniqKey="Xu B" first="Bing" last="Xu">Bing Xu</name><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name></country><country name="Pays-Bas"><noRegion><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name></noRegion><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><name sortKey="De Geus, Eco" sort="De Geus, Eco" uniqKey="De Geus E" first="Eco" last="De Geus">Eco De Geus</name><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H." last="Franco">Oscar H. Franco</name><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name><name sortKey="Mbarek, Hamdi" sort="Mbarek, Hamdi" uniqKey="Mbarek H" first="Hamdi" last="Mbarek">Hamdi Mbarek</name><name sortKey="Milaneschi, Yuri" sort="Milaneschi, Yuri" uniqKey="Milaneschi Y" first="Yuri" last="Milaneschi">Yuri Milaneschi</name><name sortKey="Penninx, Brenda" sort="Penninx, Brenda" uniqKey="Penninx B" first="Brenda" last="Penninx">Brenda Penninx</name><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G." last="Uitterlinden">André G. Uitterlinden</name><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G." last="Uitterlinden">André G. Uitterlinden</name><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name><name sortKey="Wolffenbuttel, Bruce" sort="Wolffenbuttel, Bruce" uniqKey="Wolffenbuttel B" first="Bruce" last="Wolffenbuttel">Bruce Wolffenbuttel</name></country><country name="Allemagne"><noRegion><name sortKey="Segura Lepe, Marcelo" sort="Segura Lepe, Marcelo" uniqKey="Segura Lepe M" first="Marcelo" last="Segura Lepe">Marcelo Segura Lepe</name></noRegion><name sortKey="Baumeister, Sebastian" sort="Baumeister, Sebastian" uniqKey="Baumeister S" first="Sebastian" last="Baumeister">Sebastian Baumeister</name><name sortKey="Baumeister, Sebastian" sort="Baumeister, Sebastian" uniqKey="Baumeister S" first="Sebastian" last="Baumeister">Sebastian Baumeister</name><name sortKey="Eulenburg, Volker" sort="Eulenburg, Volker" uniqKey="Eulenburg V" first="Volker" last="Eulenburg">Volker Eulenburg</name><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><name sortKey="Grabe, Hans J" sort="Grabe, Hans J" uniqKey="Grabe H" first="Hans J." last="Grabe">Hans J. Grabe</name><name sortKey="Hieber, Saskia" sort="Hieber, Saskia" uniqKey="Hieber S" first="Saskia" last="Hieber">Saskia Hieber</name><name sortKey="Huth, Cornelia" sort="Huth, Cornelia" uniqKey="Huth C" first="Cornelia" last="Huth">Cornelia Huth</name><name sortKey="Muller, Christian P" sort="Muller, Christian P" uniqKey="Muller C" first="Christian P." last="Müller">Christian P. Müller</name><name sortKey="Rawal, Rajesh" sort="Rawal, Rajesh" uniqKey="Rawal R" first="Rajesh" last="Rawal">Rajesh Rawal</name><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name></country><country name="Japon"><noRegion><name sortKey="Akira, Shizuo" sort="Akira, Shizuo" uniqKey="Akira S" first="Shizuo" last="Akira">Shizuo Akira</name></noRegion><name sortKey="Satoh, Takashi" sort="Satoh, Takashi" uniqKey="Satoh T" first="Takashi" last="Satoh">Takashi Satoh</name></country><country name="Italie"><noRegion><name sortKey="Barbieri, Caterina" sort="Barbieri, Caterina" uniqKey="Barbieri C" first="Caterina" last="Barbieri">Caterina Barbieri</name></noRegion><name sortKey="Daniela, Toniolo" sort="Daniela, Toniolo" uniqKey="Daniela T" first="Toniolo" last="Daniela">Toniolo Daniela</name><name sortKey="Pirastu, Nicola" sort="Pirastu, Nicola" uniqKey="Pirastu N" first="Nicola" last="Pirastu">Nicola Pirastu</name><name sortKey="Robino, Antonietta" sort="Robino, Antonietta" uniqKey="Robino A" first="Antonietta" last="Robino">Antonietta Robino</name><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name><name sortKey="Vuckovic, Dragana" sort="Vuckovic, Dragana" uniqKey="Vuckovic D" first="Dragana" last="Vuckovic">Dragana Vuckovic</name></country><country name="France"><noRegion><name sortKey="Cauchi, Stephane" sort="Cauchi, Stephane" uniqKey="Cauchi S" first="Stephane" last="Cauchi">Stephane Cauchi</name></noRegion><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><name sortKey="Yengo, Loic" sort="Yengo, Loic" uniqKey="Yengo L" first="Loic" last="Yengo">Loic Yengo</name></country><country name="Suède"><noRegion><name sortKey="Enroth, Stefan" sort="Enroth, Stefan" uniqKey="Enroth S" first="Stefan" last="Enroth">Stefan Enroth</name></noRegion><name sortKey="Bakalkin, Georgy" sort="Bakalkin, Georgy" uniqKey="Bakalkin G" first="Georgy" last="Bakalkin">Georgy Bakalkin</name><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name></country><country name="Estonie"><noRegion><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name></noRegion><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><name sortKey="Partinen, Eemil" sort="Partinen, Eemil" uniqKey="Partinen E" first="Eemil" last="Partinen">Eemil Partinen</name></country><country name="Finlande"><noRegion><name sortKey="H Llfors, Jenni" sort="H Llfors, Jenni" uniqKey="H Llfors J" first="Jenni" last="H Llfors">Jenni H Llfors</name></noRegion><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G." last="Eriksson">Johan G. Eriksson</name><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G." last="Eriksson">Johan G. Eriksson</name><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G." last="Eriksson">Johan G. Eriksson</name><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G." last="Eriksson">Johan G. Eriksson</name><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G." last="Eriksson">Johan G. Eriksson</name><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><name sortKey="Kaartinen, Niina" sort="Kaartinen, Niina" uniqKey="Kaartinen N" first="Niina" last="Kaartinen">Niina Kaartinen</name><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><name sortKey="Laitinen, Jaana" sort="Laitinen, Jaana" uniqKey="Laitinen J" first="Jaana" last="Laitinen">Jaana Laitinen</name><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><name sortKey="Loukola, Anu" sort="Loukola, Anu" uniqKey="Loukola A" first="Anu" last="Loukola">Anu Loukola</name><name sortKey="Loukola, Anu" sort="Loukola, Anu" uniqKey="Loukola A" first="Anu" last="Loukola">Anu Loukola</name><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><name sortKey="Wedenoja, Juho" sort="Wedenoja, Juho" uniqKey="Wedenoja J" first="Juho" last="Wedenoja">Juho Wedenoja</name></country><country name="Autriche"><noRegion><name sortKey="Hofer, Edith" sort="Hofer, Edith" uniqKey="Hofer E" first="Edith" last="Hofer">Edith Hofer</name></noRegion><name sortKey="Hofer, Edith" sort="Hofer, Edith" uniqKey="Hofer E" first="Edith" last="Hofer">Edith Hofer</name><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name></country><country name="Islande"><noRegion><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name></noRegion><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name></country><country name="Suisse"><noRegion><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltan" last="Kutalik">Zoltan Kutalik</name></noRegion><name sortKey="Marques Vidal, Pedro" sort="Marques Vidal, Pedro" uniqKey="Marques Vidal P" first="Pedro" last="Marques-Vidal">Pedro Marques-Vidal</name><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name></country><country name="Australie"><noRegion><name sortKey="Martin, Nicholas" sort="Martin, Nicholas" uniqKey="Martin N" first="Nicholas" last="Martin">Nicholas Martin</name></noRegion><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B." last="Whitfield">John B. Whitfield</name></country><country name="Grèce"><noRegion><name sortKey="Tzoulaki, Ioanna" sort="Tzoulaki, Ioanna" uniqKey="Tzoulaki I" first="Ioanna" last="Tzoulaki">Ioanna Tzoulaki</name></noRegion><name sortKey="Evangelou, Evangelos" sort="Evangelou, Evangelos" uniqKey="Evangelou E" first="Evangelos" last="Evangelou">Evangelos Evangelou</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Liu, Yun" sort="Liu, Yun" uniqKey="Liu Y" first="Yun" last="Liu">Yun Liu</name></noRegion><name sortKey="Liu, Yun" sort="Liu, Yun" uniqKey="Liu Y" first="Yun" last="Liu">Yun Liu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002516 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002516 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:5167198
|texte= KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27911795" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |